Actively Recruiting
Itraconazole Therapy In Bronchiectasis With Airway Mold
Led by Mayo Clinic · Updated on 2026-02-10
30
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to evaluate the feasibility of itraconazole therapy in patients with bronchiectasis and airway mold. Feasibility will be assessed through recruitment success, treatment adherence, tolerability, and participant retention. The study will also explore the impact on respiratory symptoms and airway microbiome diversity.
CONDITIONS
Official Title
Itraconazole Therapy In Bronchiectasis With Airway Mold
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and seen at Mycobacterial and Bronchiectasis Clinic in Rochester
- Diagnosis of bronchiectasis confirmed by clinic provider and chest CT
- Mold growth in airway cultures within the last 3 months, either many colonies of one mold or at least two different mold species
- Not currently on antimicrobial therapy and no planned antimicrobial treatment at enrollment
- Ability to produce spontaneous sputum at first visit
You will not qualify if you...
- Known allergic bronchopulmonary aspergillosis or invasive fungal disease
- Use of rifampin, rifabutin, phenobarbital, phenytoin, carbamazepine, dofetilide, quinidine, dronedarone, simvastatin, lovastatin, certain immunosuppressants, or specific anticoagulants
- Abnormal liver function tests above normal limits
- Prolonged QTc interval on ECG (>460 ms for females, >450 ms for males)
- History of congestive heart failure, cardiomyopathy, or arrhythmias
- Pregnancy or lactation
- Known allergy or contraindication to azole antifungal therapy
- Use of systemic antifungals within the past 3 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
P
Pulmonary Clinical Research Office
CONTACT
J
Jennifer McNamara, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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