Actively Recruiting
IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia
Led by University of Iowa · Updated on 2026-04-28
80
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through the intravenous, are equally effective in controlling post-operative pain
CONDITIONS
Official Title
IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years old
- Planned open abdominal surgery with an incision at or above the umbilicus
- Epidural planned and expected to be used for about 4 to 5 days
- Patient has consented to receive an epidural
- Ability to communicate in English
- Ability to use a patient-controlled pain pump
You will not qualify if you...
- Known contraindication for an epidural
- Mental or cognitive disability
- History of chronic opioid use or substance abuse
- Use of opioids before surgery
- History of chronic pain
- Routine marijuana use
- Currently incarcerated
- Unable to communicate in English
- Planned to remain intubated after surgery
- Need for blood thinners post-surgery that prevent use of epidural catheter
- End stage kidney disease or dialysis
- Liver disease affecting drug metabolism
- Known allergy or contraindication to study medications
- Known pregnancy or positive pregnancy test before surgery
- Known neurological conditions affecting motor or sensory function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
M
Melinda Seering, MD
CONTACT
Y
Yair Rubin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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