Study of IV Fluid Amounts Around ERCP and Their Effect on Post-Procedure Pancreatitis

What this Trial Is About

Researchers are studying the relationship between the amount of intravenous fluids given around the time of endoscopic retrograde cholangiopancreatography ERCP and the risk of developing post-ERCP pancreatitis PEP. ERCP is a procedure with a relatively high risk of adverse events, especially pancreatitis, which causes significant healthcare costs and patient burden. This study aims to understand whether the amount of fluid given during the procedure affects the chance of developing PEP. The study compares two groups of patients based on the volume of intravenous crystalloid fluids they receive immediately before, during, and after ERCP. One group receives aggressive hydration with 2 liters or more of fluid, while the other group receives conservative hydration with less than 1 liter. The study uses data from a previous multicenter prospective cohort to analyze these differences. Participants are adults referred for ERCP who can provide informed consent. Researchers will evaluate the occurrence of PEP within 30 days as the primary outcome. Additional information collected includes procedure details and other adverse events. Statistical methods will be used to assess the relationship between fluid volume and PEP risk. The study will monitor patients for 30 days after ERCP to measure outcomes and gather data on procedure success and adverse events.

IV Fluids and Post-ERCP Pancreatitis