Actively Recruiting
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
Led by Yale University · Updated on 2025-09-02
70
Participants Needed
1
Research Sites
177 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal. Will use pulsed IV nicotine administration which closely matches nicotine delivery by inhaled tobacco use.
CONDITIONS
Official Title
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female and male, aged 21 to 55 years
- Daily cigarette use for the past year confirmed by urine cotinine levels above 100 ng/ml
- Lifetime history of e-cigarette use
- Good health as confirmed by medical history, screening exam, and lab tests
- Women using acceptable birth control methods
You will not qualify if you...
- History of major medical or psychiatric disorders deemed unsafe for study participation
- Risk factors for EVALI including history of lung diseases like asthma or COPD, or vaping THC or CBD
- Regular use of psychotropic medications such as antidepressants, antipsychotics, or anxiolytics
- Current alcohol or substance use disorder except nicotine
- Pregnant or breastfeeding women
- Seeking or undergoing treatment for tobacco dependence
- Aversion to e-cigarettes or tobacco-flavored e-liquid
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Healthcare System
West Haven, Connecticut, United States, 06516
Actively Recruiting
Research Team
M
Mehmet Sofuoglu,, M.D.,Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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