Actively Recruiting
IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
Led by Hanoi Medical University · Updated on 2026-02-13
148
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
H
Hanoi Medical University
Lead Sponsor
H
Hanoi Obstetrics and Gynecology Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are comparing two ovarian stimulation methods used in in vitro fertilization (IVF) for women aged 20 to 45. The study aims to see if the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol result in similar numbers of mature eggs, good-quality embryos, and clinical outcomes. They will also examine differences in embryo development patterns using time-lapse imaging and compare embryo quality scores between the two approaches. Participants will be randomly assigned to one of two groups: the PPOS group will receive FSH injections along with oral Dydrogesterone 20mg daily starting from day 2 or 3 of their menstrual cycle, while the GnRH Antagonist group will receive FSH injections with GnRH antagonist added when follicles reach 12 to 14 mm. Both groups undergo controlled ovarian stimulation for about 10 to 12 days, with regular ultrasound and blood monitoring. Eggs will be retrieved when follicles mature, and embryos cultured in a time-lapse incubator before being frozen on days 5 or 6. During the study, participants will attend visits for ovarian monitoring, egg retrieval, and embryo culture. Researchers will measure the blastocyst formation rate on days 5 to 6 after egg retrieval as the main outcome, along with embryo development patterns from days 2 to 5. The study runs from January 2026 to June 2028 and includes single-blind randomization. All embryos are frozen for later transfer, and the study is conducted at the Hanoi Obstetrics and Gynecology Hospital.
CONDITIONS
Brief Title
IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 20 to 45 years
- Planned for in vitro fertilization (IVF) treatment
- Planned freeze-all embryo strategy
- Voluntary participation in research
You will not qualify if you...
- Presence of systemic diseases
- Use of hormonal medications within 3 months prior to enrollment
- Participation in oocyte donation cycles
- Unwilling or unable to participate in research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2 weeks
Participants receive ovarian stimulation using either the Progestin-Primed Ovarian Stimulation (PPOS) protocol or the GnRH antagonist protocol. All embryos are cultured using time-lapse technology and cryopreserved for subsequent frozen embryo transfer.
Multiple visits during stimulation and monitoring
Trial Site Locations
Total: 1 location
1
Hanoi Obstetrics and Gynecology Hospital
Hanoi, Vietnam, 100000
Actively Recruiting
Research Team
T
Thanh Huy Dao, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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