Comparing Intravascular Ultrasound-Guided and Angiography-Guided Coronary Stenting in Patients with Acute Coronary Syndrome

What this Trial Is About

Coronary artery disease causes significant illness and death worldwide. This trial compares two methods of guiding percutaneous coronary intervention PCI in patients with acute coronary syndrome ACS. Researchers are evaluating whether using intravascular ultrasound IVUS for PCI offers better clinical outcomes than the standard angiography guidance. The study is a prospective, multicenter, randomized controlled trial involving 1,500 participants from 15 centers in Korea, focusing on target vessel failure over two years. Participants will be randomly assigned to one of two groups PCI guided by IVUS or PCI guided by coronary angiography. In the IVUS group, ultrasound will be used before, during, and after stent placement to optimize the procedure, with mandatory post-stent assessment and possible additional treatments if needed. The angiography group will receive PCI guided by standard angiography without routine IVUS use, although IVUS may be used in bailout situations. Both groups will receive drug-eluting stents appropriate for their coronary lesions. During the study, participants will be monitored for two years for outcomes such as target vessel failure, cardiac events, and procedural measures. Assessments include clinical follow-up, angiographic evaluation, and monitoring for complications like stent thrombosis and kidney injury after contrast use. The study aims to gather detailed data on the safety and effectiveness of IVUS-guided PCI compared to angiography-guided PCI in ACS patients.

IVUS-Guided vs Angiography-Guided PCI in Acute Coronary Syndrome