Actively Recruiting
IVUS Guided PCI in Patients With Chronic Kidney Disease
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-02-07
170
Participants Needed
2
Research Sites
155 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The incidence of contrast-induced nephropathy (CIN) is high (\> 25%) in patients with severe chronic renal disease (CKD) who undergo a percutaneous coronary procedure. The development of CIN is a factor of poor prognosis and is associated with the occurrence of irreversible CKD, the need for dialysis, increased length of stay and hospital costs as well as the risk of death. There is no specific treatment for N-PCI, so its prevention is essential. Although many studies have been conducted to identify, compare and implement different pharmacological strategies for the prevention of CIN before percutaneous coronary procedurse, few per-procedural strategies have been studied to prevent this risk. Intracoronary ultrasound (IVUS) is an essential tool, used routinely to guide percutaneous coronary procedures thanks to ultrasound, it does not require the injection of iodine contrast. The main objective is to show that an IVUS-guided "zero-contrast" coronary angioplasty strategy in patients with severe renal impairment decreases the incidence of CIN within 72 hours of procedure.
CONDITIONS
Official Title
IVUS Guided PCI in Patients With Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old
- Indication for PCI
- Chronic kidney disease with creatinine clearance 430 mL/min/1.73m
- Feasibility of IVUS determined by 2 trained interventional cardiologists
- Affiliated to social security
You will not qualify if you...
- Iodine contrast injection in the previous 72 hours
- Known allergy to iodine contrast
- Permanent dialysis
- Chronic total occlusion
- Hemodynamic instability
- Legal protection
- Pregnant or breastfeeding patients
- Patients on "AME"
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Romain GALLET
Créteil, Creteil, France, 94010
Not Yet Recruiting
2
Romain GALLET
Créteil, France, 94010
Actively Recruiting
Research Team
R
Romain GALLET, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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