Actively Recruiting
JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation
Led by Allist Pharmaceuticals, Inc. · Updated on 2025-04-04
392
Participants Needed
37
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This Phase 3 study will evaluate the efficacy of JAB-21822+JAB-3312 versus tislelizumab (PD-1 Ab) combined with pemetrexed+carboplatin as the first line treatment in subjects with KRAS G12C mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
CONDITIONS
Official Title
JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent before any study procedures
- Age 18 years or older
- Histologically or cytologically confirmed locally advanced or metastatic unresectable non-squamous NSCLC with KRAS p.G12C mutation confirmed by central lab
- No prior systemic anticancer therapy for locally advanced or metastatic disease
- Expected survival of 3 months or longer
- At least one target lesion according to RECIST 1.1
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
You will not qualify if you...
- Previous (within 2 years) or current other solid tumors or blood cancers
- Presence of other driver gene mutations with available targeted therapies or other KRAS mutations
- Untreated central nervous system (CNS) metastases
- Uncontrolled pleural effusion, pericardial effusion, or ascites
- Impaired heart function or clinically significant heart disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Anhui Province cancer hospital
Hefei, Anhui, China, 230031
Not Yet Recruiting
2
Pecking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100005
Not Yet Recruiting
3
Cancer Hospital Chinese Academy Of Medical Sciences
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
4
Beijing Tiantan Hospital, Captal Medical University
Beijing, Beijing Municipality, China, 100070
Not Yet Recruiting
5
Beijing Cancer Hospital
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
6
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
7
Beijing Chest Hospital ,Capital Medical University
Beijing, Beijing Municipality, China, 101125
Actively Recruiting
8
Fujian cancer Hospital
Fuzhou, Fujian, China, 350014
Not Yet Recruiting
9
The first Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510080
Not Yet Recruiting
10
Cancer Hospital Chinese Academy Of medical Sciences Shenzhen Center
Shenzhen, Guangdong, China, 518116
Not Yet Recruiting
11
Guangxi Medical University Cancer hospital & Guangxi Cancer Institute
Nanning, Guangxi, China, 530000
Not Yet Recruiting
12
Cangzhou hospital of integrated TCM-WM Hebei
Cangzhou, Hebei, China, 061000
Actively Recruiting
13
Harbin Medical University Cancer Hospital-Mammary gland of internal
Haerbin, Heilongjiang, China, 150081
Not Yet Recruiting
14
Henan Cancer Hospital
Zhengzhou, Henan, China, 450003
Not Yet Recruiting
15
The First Affiliated Hosipital Of Zhengzhou University
Zhengzhou, Henan, China, 450052
Not Yet Recruiting
16
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Not Yet Recruiting
17
Tongji Hospital Tongji Medical College of Hust
Wuhan, Hubei, China, 430030
Not Yet Recruiting
18
Hubei cancer hospital
Wuhan, Hubei, China, 430079
Not Yet Recruiting
19
Hunan Cancer Hospital
Changsha, Hunan, China, 410031
Not Yet Recruiting
20
Jiangsu province hospital
Nanjing, Jiangsu, China, 210029
Not Yet Recruiting
21
Wuxi People's Hospital
Wuxi, Jiangsu, China, 214023
Not Yet Recruiting
22
Jilin cancer hospital
Jilin, Jilin, China, 130021
Not Yet Recruiting
23
The First Hospital Of China Medical University
Shenyang, Liaoning, China, 110001
Not Yet Recruiting
24
Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, China, 110801
Not Yet Recruiting
25
Shandong Cancer Hospital
Jinan, Shandong, China, 250012
Actively Recruiting
26
LinYi Cancer Hospital
Linyi, Shandong, China, 276002
Not Yet Recruiting
27
The affiliated hospital of Qingdao university
Qingdao, Shandong, China, 266003
Not Yet Recruiting
28
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China, 200032
Not Yet Recruiting
29
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China, 200433
Not Yet Recruiting
30
Shanxi province cancer hospital
Taiyuan, Shanxi, China, 030013
Not Yet Recruiting
31
The First Affiliated Hospital of Xi'An Jiaotong University
Xi’an, Shanxi, China, 710061
Not Yet Recruiting
32
Sichuan province cancer hospital
Chengdu, Sichuan, China, 610041
Not Yet Recruiting
33
West China Hospital Sichuan University
Chengdu, Sichuan, China, 610044
Not Yet Recruiting
34
Tianjin Medical University Cancer Institute Hospital
Tianjin, Tianjin Municipality, China, 300181
Not Yet Recruiting
35
The First affiliated hospital Zhejiang university school of medicine
Hangzhou, Zhejiang, China, 310003
Not Yet Recruiting
36
The Second Affiliated Hospital Zhejiang School of Medicine
Hangzhou, Zhejiang, China, 310003
Not Yet Recruiting
37
Taizhou Hospital Zhejiang Province
Taizhou, Zhejiang, China, 317000
Not Yet Recruiting
Research Team
S
Shanghai Allist Pharmaceuticals Co., Ltd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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