Actively Recruiting

Phase Not Applicable
Age: 18Years - 50Years
MALE
Healthy Volunteers
NCT07563036

JAK2 Expression in Androgenetic Alopecia Before and After Topical Minoxidil

Led by Kasr El Aini Hospital · Updated on 2026-05-01

25

Participants Needed

1

Research Sites

47 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Androgenetic alopecia is a common form of progressive hair loss. This prospective single-arm pre-post interventional study aims to assess tissue Janus Kinase 2 (JAK2) expression in patients with androgenetic alopecia by comparing balding and non-balding scalp at baseline, and to evaluate changes in JAK2 expression in balding scalp after 3 months of topical minoxidil 5% therapy. Clinical response will be assessed using standardized trichoscopic parameters.

CONDITIONS

Official Title

JAK2 Expression in Androgenetic Alopecia Before and After Topical Minoxidil

Who Can Participate

Age: 18Years - 50Years
MALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Male adults aged 18 to 50 years with androgenetic alopecia
  • Mild to moderate disease severity, defined as Hamilton-Norwood scale II to V
  • Treatment-naive or willing to have a washout period of at least 1 month from prior hair loss therapies
  • Able and willing to provide written informed consent
Not Eligible

You will not qualify if you...

  • Other types of hair loss, including inflammatory or scarring alopecia
  • Inflammatory scalp conditions such as psoriasis or seborrheic dermatitis
  • Use of systemic immunosuppressants, JAK inhibitors, or systemic corticosteroids within the last 12 months
  • History of severe systemic diseases like kidney, heart, or liver disease
  • Chemotherapy in the past 5 years
  • Bleeding disorders

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Kasr El Aini Hospital

Cairo, Cairo Governorate, Egypt, 11555

Actively Recruiting

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Research Team

H

Heba Ahmed

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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