Rationale and design of a mechanistic clinical trial of JAK inhibition to prevent ventilator-induced diaphragm dysfunction.
Joseph B Shrager, Yoyo Wang, Myung Lee...
https://pubmed.ncbi.nlm.nih.gov/34655959Actively Recruiting
Phase 2
Age: 18Years +
All Genders
ID03681275
A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
Led by Stanford University · Updated on 2024-11-25
70
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.
CONDITIONS
Brief Title
Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients undergoing esophagectomy
You will not qualify if you...
- Patients with more than mild pulmonary dysfunction
- Patients with any neuromuscular disease that might compromise diaphragm function
- Patients with abnormal liver or kidney function
- Patients taking any immunosuppressant medication (including prednisone) or antifungal medications
- History of tuberculosis
- Weight loss of >5% of body weight over previous 6 months
- Pregnancy
AI-Screening
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1
2
3
Trial Site Locations
Total: 1 location
1
Stanford University Medical Center
Stanford, California, United States, 94305
Actively Recruiting
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Research Team
C
Cheyenne A Clinical Research Coordinator, B.S, M.S
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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Published Research Related To This Trial
JAK inhibition with tofacitinib rapidly increases contractile force in human skeletal muscle.
Joseph B Shrager, Ryan Randle, Myung Lee...
https://pubmed.ncbi.nlm.nih.gov/39122555