Actively Recruiting
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
Led by University of Texas Southwestern Medical Center · Updated on 2026-04-16
272
Participants Needed
50
Research Sites
700 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To Determine if SAbR improves survival over SR in High Risk Operable Stage I NSCLC
CONDITIONS
Official Title
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years
- ECOG/Zubrod performance status of 0, 1, or 2
- Radiographic evidence consistent with non-small cell lung cancer, including lesions with 50% or more solid components
- Biopsy confirmation of primary lung tumor as non-small cell lung cancer within 180 days before randomization
- Tumor size 4 cm or less in maximum diameter, including clinical stage IA and selected IB by PET or PET-CT within 180 days before randomization
- Negative mediastinal lymph nodes confirmed by biopsy within 180 days before randomization if suspicious
- Tumor location suitable for sublobar resection as verified by a thoracic surgeon
- Tumor located peripherally in the lung, at least 2 cm away from the proximal bronchial tree
- No evidence of distant metastases
- Available pulmonary function tests within 180 days prior to registration, or documented high-risk operability by thoracic surgeon if unable to perform tests
- High-risk status for surgery defined by either one major criterion (FEV1 or DLCO ≤ 50%, or surgeon's assessment) or two minor criteria (age ≥ 75, FEV1 or DLCO 51-60%, pulmonary hypertension, poor left ventricular function, low arterial oxygen, elevated pCO2, or dyspnea scale ≥ 3)
- No prior intra-thoracic radiation on the same side as the tumor
- No prior chemotherapy, radiotherapy, or surgery for the current lung cancer
- No prior lung resection on the same side
- Non-pregnant and non-lactating; women of childbearing potential must have a negative pregnancy test
- No prior invasive malignancy unless disease-free for 3 or more years
- Ability to understand and sign informed consent
You will not qualify if you...
- Age less than 18 years
- ECOG/Zubrod performance status greater than 3
- Radiographic lesions with less than 50% solid component
- Biopsy confirmation of lung cancer more than 180 days before randomization
- Tumor larger than 5 cm or staging imaging older than 180 days before randomization
- Lymph node biopsy older than 180 days before randomization
- Tumor not removable by sublobar resection as confirmed by surgeon
- Tumor located in central lung region (not peripheral)
- Evidence of distant metastases
- Pulmonary function tests older than 180 days before registration without surgeon's documentation
- Not meeting defined major or minor high-risk criteria for surgery
- Prior intra-thoracic radiation on the same side or recent overlapping contralateral radiation
- Previous chemotherapy, radiotherapy, or surgery for the lung cancer treated in this study
- Prior lung resection on the same side
- Pregnant or lactating women
- Prior invasive malignancy with less than 3 years disease-free interval
- Unable to understand or sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 50 locations
1
UCSD
La Jolla, California, United States, 92023
Completed
2
University of Colorado/Memorial
Aurora, Colorado, United States, 80045
Completed
3
Penrose Cancer Center
Colorado Springs, Colorado, United States, 80907
Completed
4
Boca Raton Regional Hospital
Boca Raton, Florida, United States, 33486
Completed
5
Curtis and Elizabeth Anderson Cancer
Savannah, Georgia, United States, 31404
Actively Recruiting
6
University of Iowa
Iowa City, Iowa, United States, 52242
Terminated
7
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Completed
8
University of Kentucky Health Care
Lexington, Kentucky, United States, 40536-0093
Completed
9
University of Louisville Physicians
Louisville, Kentucky, United States, 40202
Active, Not Recruiting
10
Ochsner Medical Center
New Orleans, Louisiana, United States, 70121
Completed
11
Luminis Health Research Institute
Annapolis, Maryland, United States, 21401
Active, Not Recruiting
12
University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Completed
13
Boston Medical Center
Boston, Massachusetts, United States, 02118
Completed
14
Henry Ford Health System
Detroit, Michigan, United States, 48202-2689
Completed
15
Beaumont
Royal Oak, Michigan, United States, 48073
Completed
16
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Completed
17
Meridian Health System
Neptune City, New Jersey, United States, 07753
Actively Recruiting
18
New York University Langone Medical Center
New York, New York, United States, 10016
Active, Not Recruiting
19
SUNY - Upsate Medical Centre
Syracuse, New York, United States, 13210
Actively Recruiting
20
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Completed
21
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States, 27157
Completed
22
University of Cincinnati
Cincinnati, Ohio, United States, 45267
Completed
23
Case Western (University Hospitals Case Medical Center)
Cleveland, Ohio, United States, 44106
Completed
24
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Active, Not Recruiting
25
Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210
Active, Not Recruiting
26
Providence Health & Services/Oregon Clinic
Portland, Oregon, United States, 97213
Completed
27
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Completed
28
Allegheny
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
29
UPMC Health System
Pittsburgh, Pennsylvania, United States, 15234
Completed
30
Mount Nittany
State College, Pennsylvania, United States, 16803
Completed
31
Lifespan Oncology Clinical Research
Providence, Rhode Island, United States, 02903
Completed
32
University of Tennessee Health Science Center
Memphis, Tennessee, United States, 38163
Completed
33
Cardiothoracic and Vascular Surgeons
Austin, Texas, United States, 78756
Completed
34
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
35
Intermountain Medical Center
Salt Lake City, Utah, United States, 84107
Completed
36
University of Virginia Health System
Charlottesville, Virginia, United States, 22901
Completed
37
Inova Fairfax Medical Campus
Falls Church, Virginia, United States, 22042
Completed
38
Swedish Cancer Institute
Seattle, Washington, United States, 98104
Completed
39
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Completed
40
Clement Zablocki VA Medical Center
Milwaukee, Wisconsin, United States, 53295
Completed
41
St. Vincent's Hospital Melbourne
Fitzroy, Melbourne, Australia, 3065
Actively Recruiting
42
St. Vincent's/Peter Mac
Fitzroy, Victoria, Australia, 3065
Actively Recruiting
43
Barwon Health - Uni Hospital Geelong
Geelong, Victoria, Australia, 3220
Actively Recruiting
44
Trillium Health Partners
Mississauga, Canada, Canada, L5M 2N1
Completed
45
Sunnybrook Health Sciences Centre
Toronto, Canada, Canada, M4N 3M5
Completed
46
Ottawa Hospital Cancer Center
Ottawa, Ontario, Canada, KIH8L6
Actively Recruiting
47
UHN-Toronto
Toronto, Ontario, Canada, M5G2C4
Actively Recruiting
48
Lawson Health Science Center
London, Ontario, Canada, Canada, N6C 2R5
Actively Recruiting
49
CHUM
Montreal, Quebec, Canada, 26214
Actively Recruiting
50
The James Cook University Hospital
Middlesbrough, United Kingdom, TS4 2BW
Active, Not Recruiting
Research Team
S
Sarah Neufeld, MBA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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