Actively Recruiting
JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction in Patients Aged 10 to 35
Led by Hospital for Special Surgery, New York · Updated on 2026-02-13
850
Participants Needed
16
Research Sites
52 weeks
Total Duration
On this page
Sponsors
H
Hospital for Special Surgery, New York
Lead Sponsor
A
American Orthopaedic Society for Sports Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the outcomes of medial patellofemoral ligament (MPFL) reconstruction surgery for people with recurrent patellar instability, a condition where the kneecap frequently dislocates. This observational study aims to identify risk factors that lead to repeated instability after surgery and to assess how patients function and feel after the procedure. The study is conducted by a group of high-volume surgeons across the United States who treat this condition. Participants will undergo isolated MPFL reconstruction, which involves reconstructing the ligament with a tendon graft. Additional soft tissue procedures like lateral retinacular lengthening, release, chondroplasty, or cartilage restoration may be performed, but no bone realignment surgeries are included. The study enrolls patients aged 10 to 35 years with recurrent patellar instability, and follows them for up to 24 months after surgery. During the study, participants will answer surveys about their knee function and activity levels at 1 year and 2 years after surgery. Researchers will monitor the occurrence of recurrent dislocations within 24 months and assess patient-reported outcome measures such as the Kujala score, Pedi-IKDC, HSS Pedi-FABS, KOOS-12, BPII 2.0, and PROMIS-29. The goal is to better understand which factors influence surgical success and to improve treatment planning for future patients.
CONDITIONS
Brief Title
JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 10 and 35 years
- Recurrent patellar instability with at least one episode defined by (1) a dislocated patella requiring emergency reduction or (2) a convincing history of dislocation with full giving way and physical signs such as hemarthrosis, medial retinaculum tenderness, and apprehension on lateral force or (3) MRI-documented dislocation with bone bruises
You will not qualify if you...
- Previous surgery on the same knee
- Fixed, habitual, or obligatory patella dislocation or subluxation
- Severe inferior or lateral cartilage damage on the patella needing tibial tubercle transfer
- Pathologic instability of the tibiofemoral joint
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and up to 2 weeks post-operatively
Participants undergo isolated Medial Patellofemoral Ligament (MPFL) reconstruction surgery and receive immediate post-operative care.
1 surgery day and several early follow-up visits
Duration - Up to 24 months post-operatively
Participants have follow-up visits to monitor recovery, assess knee stability, and complete patient-reported outcome measures.
Visits at 12 months and 24 months post-operatively
Trial Site Locations
Total: 16 locations
1
Stanford University
Redwood City, California, United States, 94063
Actively Recruiting
2
University of Florida
Gainesville, Florida, United States, 32607
Actively Recruiting
3
Midwest Orthopaedics at Rush
Chicago, Illinois, United States, 60612
Actively Recruiting
4
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
5
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
6
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
7
Mayo Clinic
Rochester, Minnesota, United States, 55905
Not Yet Recruiting
8
Mount Sinai
New York, New York, United States, 10012
Not Yet Recruiting
9
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
10
Hospital for Special Surgery
New York, New York, United States, 10021
Actively Recruiting
11
Duke Health
Wake Forest, North Carolina, United States, 27587
Actively Recruiting
12
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
13
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
14
Ohio State University Wexler Medical Center
Dublin, Ohio, United States, 43016
Actively Recruiting
15
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
16
Scottish Rite for Children
Dallas, Texas, United States, 75219
Actively Recruiting
Research Team
S
Simone Gruber
N
Natalie Pahapill
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here