Study on How Healthy Adults Absorb and Process Kaempferol, a Natural Plant Compound

What this Trial Is About

Researchers are evaluating how the body absorbs and processes Kaempferol, a natural compound found in many plant-based foods, in healthy adults. This multi-site clinical trial aims to measure the pharmacokinetics and biological absorption of Kaempferol, providing important human data to support future research and regulatory planning. The study addresses gaps in current knowledge by using standardized procedures across multiple U.S. clinical sites. Participants receive oral Kaempferol capsules once daily for 8 days under controlled dietary conditions. During this period, they undergo scheduled blood and urine collections at predefined time points to measure Kaempferol levels and metabolites. The study also includes comprehensive multi-omics analyses, such as genomics, transcriptomics, metabolomics, lipidomics, and proteomics, to explore biological responses to Kaempferol exposure. Safety and tolerability are monitored throughout. Participants are involved in clinic visits with serial biospecimen collections, including blood and urine samples. Researchers assess pharmacokinetic profiles, molecular changes, and biomarkers related to oxidative stress, inflammation, and metabolic health. Safety is monitored through reported symptoms, clinical assessments, and laboratory tests. The study maintains participant confidentiality with coded data and secure storage, and all activities are overseen by institutional review boards.

Kaempferol Absorption and Pharmacokinetics Evaluation