Actively Recruiting
Kaempferol Absorption and Pharmacokinetics Evaluation
Led by University of Pittsburgh · Updated on 2026-03-23
120
Participants Needed
3
Research Sites
106 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
O
Otsuka Pharmaceutical Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a multi-site clinical trial designed to evaluate how the body absorbs and processes Kaempferol, a naturally occurring compound found in many plant-based foods. The primary purpose of the study is to measure the pharmacokinetics and biological absorption of Kaempferol in healthy adults. Participants will receive Kaempferol and undergo scheduled blood and urine collections over a short study period. These samples will be used to measure Kaempferol levels in the body and to assess safety and tolerability. In addition, selected biological samples will be analyzed to explore molecular changes associated with Kaempferol exposure using advanced laboratory methods. The study will be conducted at multiple research centers in the United States using a standardized protocol to ensure consistency across sites. The information collected will help improve understanding of how Kaempferol is absorbed and metabolized in humans and will support future research and regulatory evaluation.
CONDITIONS
Official Title
Kaempferol Absorption and Pharmacokinetics Evaluation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 70 years
- Healthy volunteers as determined by medical history and screening assessment
- Ability to understand the study procedures and provide informed consent
- Willingness and ability to comply with all study procedures, including dietary restrictions, clinic visits, blood draws, urine collection, and follow-up assessments
- Willingness to abstain from restricted foods, beverages, and supplements as specified in the study protocol during the study period
You will not qualify if you...
- Known allergy or hypersensitivity to Kaempferol or related flavonoids
- Pregnancy or breastfeeding
- Presence of significant acute or chronic medical conditions that could increase risk or interfere with study outcomes, including active or chronic infections, cancer, cardiovascular disease, neurological or neurodegenerative disorders, metabolic or systemic inflammatory conditions
- Use of prescription medications or supplements known to interfere with Kaempferol metabolism or pharmacokinetic assessment
- Blood donation within 8 weeks prior to study enrollment
- Participation in another interventional clinical study within a timeframe that could interfere with study results or participant safety
- Any condition or circumstance that, in the judgment of the study investigator, would make participation unsafe or compromise data integrity
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Weill Cornell Medicine
New York, New York, United States, 10065
Not Yet Recruiting
2
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Not Yet Recruiting
3
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15219
Actively Recruiting
Research Team
A
Afshin Beheshti, PhD
CONTACT
A
Arabella Johnson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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