Actively Recruiting
Karolinska Schizophrenia Project
Led by Karolinska Institutet · Updated on 2025-03-12
200
Participants Needed
1
Research Sites
1144 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
R
Region Stockholm
Collaborating Sponsor
AI-Summary
What this Trial Is About
KaSP is a multimodal observational study with the goal of clarifying underlying mechanisms that cause psychotic disorders, such as schizophrenia. Participants with psychotic symptoms are recruited early after first contact with health care, within 4 weeks of starting anti-psychotic medication, and are compared to controls without psychiatric diagnoses on several measures.
CONDITIONS
Official Title
Karolinska Schizophrenia Project
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of schizophrenia, schizophreniform psychosis, psychosis not otherwise specified, brief psychosis, schizoaffective syndrome, or delusional disorder as per DSM-IV
- First exposure to anti-psychotic medication less than 4 weeks prior to enrollment
You will not qualify if you...
- Other dominant psychiatric illness related to current psychotic symptoms
- History of major psychiatric disorder or substance use disorder (for healthy controls)
- Family history of psychotic disorders in first-degree relatives (for healthy controls)
- Clinically significant somatic disorders or prior brain disorders such as tumor, neuroinflammatory disease, epilepsy, or significant brain trauma
- Exposure to radiation dose of 25 mSv or more in the past year
- Pregnancy, lactating, or breastfeeding
- Substance use disorder (excluding nicotine), or repeated positive urine screens during study
- Metallic objects in the eye, ferro/electromagnetic implants, or claustrophobia during MRI
- Severe infections with systemic effects within 7 days before inclusion
- Treatment with antihemostatic medication within 2 weeks before lumbar puncture or arterial line placement
- Blood donation within 90 days before screening, plasma donation within 1 week, or platelet donation within 6 weeks before inclusion
- Other reasons judged by Investigator or Sponsor making participant unsuitable, including very severe symptoms or hostility
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
SLSO Psykiatri Stockholm in collaboration w Karolinska Institutet
Stockholm, Sweden
Actively Recruiting
Research Team
C
Carl M Sellgren, MD, PhD
CONTACT
L
Lena Lundberg
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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