Actively Recruiting
KD Treatment for Super-refractory Status Epilepticus
Led by Xuanwu Hospital, Beijing · Updated on 2026-03-27
84
Participants Needed
15
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to investigate to evaluate the efficacy and safety of ketogenic diet (KD) as an adjunctive therapy in patients with Super Refractory Status Epilepticus (SRSE) in the intensive care unit (ICU).
CONDITIONS
Official Title
KD Treatment for Super-refractory Status Epilepticus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with super-refractory status epilepticus (SRSE) that continues or returns after initial treatment including benzodiazepines, anti-seizure medication, and continuous anesthetic for 24 hours
- Age between 14 and 80 years, any gender
- Signed informed consent provided by the patient's legal guardian
You will not qualify if you...
- Patients with lipid metabolism disorders such as carnitine deficiency, fatty acid oxidation defects, and related enzyme deficiencies
- Intolerance to enteral feeding (e.g., intestinal obstruction)
- Receipt of propofol infusion within 24 hours
- Hemodynamic instability requiring high-dose vasopressors (systolic BP <90 mmHg or diastolic BP <60 mmHg)
- Liver failure with elevated liver enzymes, blood ammonia, or bilirubin levels
- Pancreatitis
- Pregnancy
- Metabolic instability including low blood glucose, acidic blood pH, or abnormal sodium levels
- Complications from sepsis
- Complications from diabetes insipidus
- Status epilepticus caused by hypoxic-ischemic brain injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230022
Actively Recruiting
2
Department of Neurology, Xuanwu Hospital Capital Medical University
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
3
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
4
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China, 530021
Actively Recruiting
5
Guizhou Provincial People's Hospital
Guiyang, Guizhou, China, 550002
Actively Recruiting
6
The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China, 570311
Not Yet Recruiting
7
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050031
Actively Recruiting
8
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150001
Actively Recruiting
9
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Not Yet Recruiting
10
Chifeng Municipal Hospital
Chifeng, Neimenggu, China, 024000
Actively Recruiting
11
Qilu Hospital，Shandong University
Jinan, Shandong, China, 2500012
Not Yet Recruiting
12
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hanzhou, Zhejiang, China, 310009
Actively Recruiting
13
Beijing Tongren Hospital, Capital Medical University
Beijing, China, 100730
Not Yet Recruiting
14
The First Hospital of Jilin University
Jilin, China, 130021
Actively Recruiting
15
Liaocheng People's Hospital
Liaocheng, China, 252000
Actively Recruiting
Research Team
W
Weibi Chen
CONTACT
G
Gang Liu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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