Actively Recruiting

Phase Not Applicable
Age: 18Years - 40Years
All Genders
NCT07273747

Kelulut Honey for Allergic Conjunctivitis and Dry Eye Symptoms

Led by Universiti Sains Malaysia · Updated on 2025-12-09

72

Participants Needed

1

Research Sites

49 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if oral Kelulut honey works to improve eye symptoms in adults with allergic conjunctivitis. It will also look at how safe Kelulut honey is when taken as a daily supplement. The main questions it aims to answer are: 1. Does oral Kelulut honey reduce itchy, red, watery eyes and dry eye symptoms in people with allergic conjunctivitis? 2. Does oral Kelulut honey improve tear film stability and the health of conjunctival goblet cells (special cells on the eye surface that help keep the eye moist)? 3. What side effects or medical problems do participants have when taking Kelulut honey? Researchers will compare oral Kelulut honey to a honey-flavoured placebo syrup (a look-alike drink that does not contain Kelulut honey) to see if Kelulut honey is more effective than placebo for treating eye symptoms in allergic conjunctivitis. Participants will: 1. Take either oral Kelulut honey or a honey-flavoured placebo syrup every day for 1 month 2. Continue their usual treatment for allergic conjunctivitis and dry eye disease as prescribed by their eye doctor 3. Attend clinic visits for eye check-ups, including tests of tear film stability, dry eye symptoms, and eye surface health 4. Answer questionnaires about their eye symptoms and how these affect their daily activities and vision-related quality of life Participation is voluntary, and participants may stop taking part in the study at any time. Data collected up to the time they withdraw may still be used for research, but their routine medical care will not be affected

CONDITIONS

Official Title

Kelulut Honey for Allergic Conjunctivitis and Dry Eye Symptoms

Who Can Participate

Age: 18Years - 40Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18-40 years old
  • Confirmed diagnosis of allergic conjunctivits
  • Ocular surface disease index (OSDI) score > 12
  • Compliance to conventional allergic conjunctivitis treatment
Not Eligible

You will not qualify if you...

  • Any corneal or ocular surface pathology
  • Known diabetes mellitus or impaired glucose test
  • Ocular surface disease due to trachoma or other inflammatory conditions
  • Use of anti-inflammatory medications such as steroids, NSAIDS, oral doxycycline
  • Concurrent use of other supplements or alternative therapies such as royal jelly, Manuka honey eye drop or omega-3 fatty acid
  • Using preservative-containing topical eye drops for ocular problems other than allergic conjunctivitis
  • History of ocular trauma/surgery or refractive surgery within last 3 years
  • Wearing contact lens in the last 3 months
  • Underlying inflammatory/systemic disease and connective tissue diseases
  • Recent conjunctivitis in the last 3 months
  • Patients on immunosuppressant

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Hospital Pakar Universiti Sains Malaysia

Kota Bharu, Kelantan, Malaysia, 16150

Actively Recruiting

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Research Team

S

Sharifah Izzati Dr, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

3

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