Actively Recruiting
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
Led by VA Office of Research and Development · Updated on 2025-12-18
44
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a pilot study to evaluate the feasibility, acceptability, and safety of ketamine infusions followed by a brief behavioral intervention in Veterans with chronic low back pain and depression.
CONDITIONS
Official Title
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans with moderate to severe chronic low back pain lasting at least 3 months and significant pain interference
- Current significant depressive symptoms based on a standard depression questionnaire
- Medically stable without hospitalizations longer than 3 days in the past month
- No changes in pain or depression medications in the past 4 weeks
- No planned surgery, injections, hospitalizations, or new treatments for back pain or depression during the next 4 months except physical therapy or exercise
- Must have an adult available to drive home after ketamine treatments
You will not qualify if you...
- Cannot speak English
- Unable or unwilling to provide written informed consent
- Current psychotic symptoms or history of psychotic disorders like schizophrenia
- Currently enrolled in another clinical trial for pain or depression
- Uncontrolled high blood pressure above specified levels
- Known elevated intracranial pressure, cerebral aneurysm, or elevated eye pressure
- History of liver cirrhosis or unstable heart condition
- Abnormal lab values exceeding twice the normal limits for certain liver, kidney, or thyroid tests
- Positive pregnancy test or no birth control in Veterans who can become pregnant
- Allergy to ketamine injection ingredients
- Previous serious adverse reaction to ketamine
- Positive drug screen for non-prescribed substances (except cannabis) on infusion day
- Current or past ketamine abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, Michigan, United States, 48105-2303
Actively Recruiting
Research Team
V
Victoria D Powell, MD
CONTACT
S
Sarah L Krein, PhD RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
OTHER
Number of Arms
3
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