Actively Recruiting
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
Led by Cairo University · Updated on 2026-03-17
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.
CONDITIONS
Official Title
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with coronary artery disease
- Moderate to severe left ventricular dysfunction (ejection fraction < 40%)
- Scheduled for elective coronary artery bypass graft surgery
You will not qualify if you...
- History of chronic stroke, transient ischemic attack, carotid occlusive disease, or neurological impairment such as cerebral infarction or dementia
- Significant carotid artery stenosis
- Valvular heart disease
- Persistent arrhythmias
- Congestive cardiac failure
- Currently on mechanical ventilation
- Use of intra-aortic balloon pump
- Emergency surgery
- Known allergy to any study drugs
- Severe systemic non-cardiac disease
- Baseline NIRS reading below 60%
- Dementia or visual or auditory impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kasr Alainy Hospital
Cairo, Egypt, 11562
Actively Recruiting
Research Team
M
Maha Mostafa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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