Actively Recruiting
Ketamine for Methamphetamine Use Disorder
Led by University of Texas Southwestern Medical Center · Updated on 2026-04-01
120
Participants Needed
5
Research Sites
109 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD. The study design is a 12-week randomized, double-blind, controlled trial comparing intravenous (IV) ketamine against IV midazolam, delivered over six weeks in 120 adults with moderate to severe methamphetamine use disorder (MUD).
CONDITIONS
Official Title
Ketamine for Methamphetamine Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 18 to 65 years old
- Be able to sufficiently understand, speak, and read English
- Be interested in reducing or stopping methamphetamine use
- Meet criteria for methamphetamine use disorder
- Use acceptable methods of contraception during participation in the study
You will not qualify if you...
- Have been in a research study of pharmacological or behavioral treatment for addiction within 6 months prior to written informed consent
- Be currently in jail, prison, or inpatient overnight facility as required by court of law
- Have upcoming surgery planned or scheduled
- Be currently pregnant, breastfeeding, or planning on conception, if biologically female
- Additional inclusion and exclusion criteria will be assessed by the study investigators at the screening visit.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
Alameda Health System
San Leandro, California, United States, 94578
Actively Recruiting
2
Interdisciplinary Substance Use and Brain Injury Facility
Albuquerque, New Mexico, United States, 87106
Completed
3
Addiction Institute of Mount Sinai
New York, New York, United States, 10029
Terminated
4
Prisma Health
Greenville, South Carolina, United States, 29617
Actively Recruiting
5
UT Southwestern Medical Center
Dallas, Texas, United States, 75247
Active, Not Recruiting
Research Team
A
Angela Casey-Willingham
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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