Ketamine for perioperative pain management.
Sabine Himmelseher, Marcel E Durieux
https://pubmed.ncbi.nlm.nih.gov/15618805Actively Recruiting
Phase 4
Age: 18Years - 100Years
All Genders
ID04248205
Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial
Led by University of Oklahoma · Updated on 2026-04-01
100
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of ketamine for pain relief after surgery in patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids. This prospective, randomized study compares intraoperative ketamine infusion with no ketamine in about 100 patients. Participants will not know which treatment they receive, but the doctors will, to examine the differences in post-operative pain and narcotic use. Participants are randomly assigned to one of two groups: one receives a ketamine dose of 0.3 mg/kg intravenously before surgery and an additional dose if the procedure lasts longer than one hour, along with standard general anesthesia and local nerve block. The other group receives standard anesthesia without ketamine. All participants receive pre-medications including Gabapentin, Ultram, and Tylenol, and will have surgery performed by one of three surgeons using the same ligasure hemorrhoidectomy method. During and after surgery, participants will track their pain using numeric and facial scales and will be contacted for pain assessments on several post-operative days. Follow-up occurs at two weeks post-surgery to count remaining narcotic pills and review recovery. Data collected include narcotic use and pain levels over 10 days. The study aims to analyze these outcomes after all participants complete follow-up, expected over 8 to 12 months.
CONDITIONS
Brief Title
Ketamine for Post-operative Analgesia in Hemorrhoidectomy
Who Can Participate
Age: 18Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 100 years
- Undergoing hemorrhoidectomy surgery for Grade III or IV hemorrhoids
You will not qualify if you...
- Unable to undergo general anesthesia
- Contraindications to hemorrhoidectomy surgery
- History of schizophrenia or other hallucinatory psychiatric illnesses
- History of psychosis
- Chronic narcotic use defined as having a pain contract with a pain management specialist and no narcotic use for one month prior to surgery is excluded if not met
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Surgery day
Participants undergo hemorrhoidectomy surgery with general anesthesia. Those randomized to the ketamine group receive an intraoperative ketamine infusion for post-operative pain management, while the control group receives standard anesthesia without ketamine.
1 visit (in-person surgery and anesthesia administration)
Post-operative Follow-up
Duration - 2 weeks
Participants follow post-operative care instructions at home, including pain medication and self-monitoring of pain. They are contacted by the research team to assess pain levels and attend a post-operative clinic visit at 2 weeks for medication usage assessment and further pain evaluation.
1 clinic visit and multiple phone contacts for pain assessment
Trial Site Locations
Total: 1 location
1
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
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Research Team
S
Steven N Carter, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Intravenous sub-anesthetic ketamine for perioperative analgesia.
Andrew W Gorlin, David M Rosenfeld, Harish Ramakrishna
https://pubmed.ncbi.nlm.nih.gov/27275042Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.
Tonny Stone Luggya, Tony Roche, Lameck Ssemogerere...
https://pubmed.ncbi.nlm.nih.gov/29062346