Actively Recruiting
Ketamine and Propofol NeuroImaging
Led by Keith M Vogt · Updated on 2026-04-15
60
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
Sponsors
K
Keith M Vogt
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combination.
CONDITIONS
Official Title
Ketamine and Propofol NeuroImaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18-59 years of age
- No specific exclusion criteria present
- Have a valid email address and phone number for the study duration
- Free from any non-MRI compatible implants
You will not qualify if you...
- Pregnant or trying to conceive
- Body mass index (BMI) greater than 35
- Significant memory impairment or hearing loss
- Sleep apnea
- Chronic pain or frequent pain medication use
- Chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol)
- Neurologic diseases including seizures or tremor
- Psychiatric diagnoses including anxiety, depression, panic, or PTSD
- History of abnormal heartbeats, liver or kidney disease, or significant lung disease
- Severe claustrophobia or intolerance to MRI
- Metal implants or non-removable metal piercings
- History of adverse reaction to ketamine or propofol
- Daily alcohol or heavy alcohol use; history of alcohol abuse
- Current daily smoker
- Regular or recent marijuana use (including prescribed/medical marijuana)
- Illicit drug use
- Regular use of antiepileptics, antidepressants, antipsychotics, antihistamines, anti-anxiety medications, stimulants, or sleep aids
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
K
Keith M Vogt, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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