Study of Ketamine Compared to Propofol Sedation After Out-of-Hospital Cardiac Arrest in Adults

What this Trial Is About

Out-of-hospital cardiac arrest OHCA is a life-threatening emergency often leading to brain injury due to lack of oxygen and blood flow. Despite improvements in resuscitation, survivors frequently face poor neurological outcomes. This trial investigates whether using ketamine as a sedative after OHCA can provide better brain protection compared to the commonly used sedative propofol. The study is a phase 2 randomized trial aiming to find a more effective neuroprotective approach for these patients. Participants will receive either intravenous or intraosseous bolus doses of ketamine at a minimum of 0.5 mgkg or propofol at a minimum of 0.25 mgkg during the prehospital phase following resuscitation. The study compares these two sedatives to assess their effects on brain injury markers and neurological recovery. The trial includes a quadruple masking design to ensure unbiased results. During the study, researchers will measure neuron-specific enolase levels 48 hours after cardiac arrest to assess brain cell injury. They will also evaluate neurological outcomes using the modified Rankin Score and Cerebral Performance Categories at discharge, 180 days, and 240 days after OHCA. Death from any cause will be monitored up to 180 days post-arrest. Participants will be closely followed to understand the long-term effects of the sedatives on brain function and survival.

Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest