Study of the Modified Atkins Diet for Treating Central Obesity in Children and Young Adults with Brain Tumors

What this Trial Is About

Researchers are evaluating the effects of the ketogenic diet in children and young adults aged 7 to 30 years who have hypothalamic-chiasmatic tumors. These tumors can disrupt hypothalamic function, leading to central obesity that is difficult to treat with drugs or lifestyle changes. The study aims to see if the ketogenic diet can help reduce excessive weight gain caused by this condition, which is often resistant to conventional treatment. Participants will follow a modified Atkins diet, a type of ketogenic diet chosen for easier adherence. This open-label, single-arm trial monitors patients over 24 months to assess weight loss and metabolic improvements. The diet promotes the use of ketone bodies as an energy source for the brain, which has been effective in other neurological conditions. During the study, researchers will track weight changes, ketosis levels, lipid and carbohydrate parameters, and lean body mass. They will also monitor safety by recording any serious adverse events and adherence rates to the diet. Participants will be followed throughout the 24-month period to evaluate both benefits and risks of this dietary intervention.

KETO-TUMOR: a Study on Brain Tumors and Central Obesity