Ketogenic Diet Treatment for Adults with Acromegaly Under Stable Medication

What this Trial Is About

Acromegaly is a condition caused by a tumor in the pituitary gland that produces too much growth hormone, leading to symptoms like enlarged body parts, fluid retention, snoring, and excessive sweating. This condition increases the risk of insulin resistance, diabetes, high blood pressure, sleep apnea, and cardiovascular disease, which can reduce quality of life and increase mortality. Normalizing hormone levels improves survival but does not fully restore quality of life or reduce all symptoms. Surgery and somatostatin analogues are common treatments, but only about 40% of patients achieve hormone normalization with medication. This trial compares two diets for people with acromegaly who are on stable somatostatin analogue treatment a ketogenic diet low in carbohydrates and a Mediterranean diet following national healthy food guidelines. Participants in the ketogenic diet group follow a strict low-carbohydrate diet 30-40 grams per day for three months, then a less strict ketogenic diet 50-60 grams carbohydrate per day for another three months. The control group follows a Mediterranean diet for six months. The study is randomized with single masking. Participants will have their insulin-like growth factor 1 IGF-1 levels measured at the start of the study, after three months, and after six months to assess treatment effects. The study also monitors symptoms, metabolic changes, and quality of life. The total participation lasts six months, with continued evaluation of hormone levels and health during this period to understand how diet impacts acromegaly management alongside medication.

KETOgenic Diet Therapy in Patients With ACROmegaly