Actively Recruiting
Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.
Led by Ohio State University · Updated on 2025-05-14
60
Participants Needed
1
Research Sites
187 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones. Ketones are small molecules that appear in the blood when following a ketogenic diet or consuming ketone supplements. The goal of this project is to find out if diet and/or ketones can improve sleep deprivation detriments over 5 days of sleep restriction (-50% from habitual sleep).
CONDITIONS
Official Title
Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 18 to 40 years
- Body mass index (BMI) between 20 and 35 kg/m2
- Habitually sleep at least 7 hours per night
- Willing to participate in about 9 weeks of testing and to eat provided food
- Able to follow all study procedures
You will not qualify if you...
- Younger than 18 or older than 40 years
- Body mass index (BMI) over 35
- Diagnosed sleep disorders such as sleep apnea or insomnia
- Gastrointestinal disorders or food allergies interfering with study supplements
- Drinking more than 3 alcoholic drinks per day or 14 drinks per week
- Conditions or contraindications preventing blood draws
- Diagnosed diabetes, liver, kidney, or other metabolic/endocrine disorders or use of diabetic medications except metformin
- Current or recent (last 3 months) low carbohydrate or ketogenic diet
- Weight loss greater than 10% of body weight in the last 6 months
- Pregnant, lactating, or planning pregnancy during the study
- Major psychiatric disorders like schizophrenia or bipolar disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
J
Jeff S Volek, PhD, RD
CONTACT
M
Madison L Kackley, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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