Effect of Ketone Monoester Supplements on Brain Blood Flow During Exercise at Low and High Altitudes

What this Trial Is About

Researchers are studying how acute ingestion of ketone monoester affects brain blood flow and ventilatory threshold during maximal exercise tests at both low and high altitudes. The trial focuses on healthy adults aged 18 to 35 and aims to understand the bodys responses to exercise under different altitude conditions while using this dietary supplement. Participants receive either a ketone monoester supplement dosed at 0.6 grams per kilogram of body weight or a taste-matched placebo. The study includes two experimental settings one at high altitude 3800 meters at Barcroft Research Station and another at low altitude 334 meters at the University of Guelph. The intervention is randomized and double-blind to compare the effects in these two environments. During the study, participants undergo maximal exercise tests with continuous monitoring of cerebral blood velocity, cardiac output, blood pressure, ventilation, oxygen consumption, carbon dioxide production, blood lactate, and beta-hydroxybutyrate levels. These measurements are taken over a 3-hour period to evaluate physiological responses. The trial lasts for the duration of the exercise test sessions, and safety is monitored throughout.

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise