Actively Recruiting
Single Blind Randomized Controlled Trial to Evaluate Ketorolac Injections for Upper Extremity Tendinopathy and Arthropathy
Led by Emory University · Updated on 2025-08-24
160
Participants Needed
4
Research Sites
N/A
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
A
American Association for Hand Surgery: AAHS
Collaborating Sponsor
AI-Summary
What this Trial Is About
Osteoarthritis and inflammatory conditions affecting the tendons and joints of the shoulder, elbow, hand, and wrist are common and can cause significant pain and disability. This research aims to evaluate and compare the effects of ketorolac and triamcinolone injections for treating tendinopathy or arthropathy in these upper extremity areas. These conditions often reduce strength and daily function, and current treatments focus on managing symptoms rather than curing the disease. Participants in this study will be randomly assigned to receive either a ketorolac injection, a non-steroidal anti-inflammatory drug that reduces inflammation, or a triamcinolone injection, a corticosteroid that decreases inflammation. Both injections will be given using standard techniques by the treating physician. The study lasts for 24 weeks, with an important follow-up visit scheduled 6 weeks after the injection to assess outcomes. During the study, participants will have their pain levels measured using a visual analog scale, along with assessments of function and strength through questionnaires and physical tests at baseline, 6 weeks, and 24 weeks. These include patient-reported outcome measures, hand function assessments, and grip strength tests. The study will monitor the effects of the injections to help understand how best to manage wrist and hand joint conditions conservatively.
CONDITIONS
Brief Title
Ketorolac in Upper Extremity Tendinopathy and Arthropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist
- No prior surgical treatment for the condition
- Diagnoses may include trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis
You will not qualify if you...
- Under 18 years of age
- Prior triamcinolone or ketorolac injections within the past 6 months
- Previous surgical treatment for the hand condition
- Allergy or contraindication to triamcinolone or ketorolac injections
- Active infection at the treatment site, including cellulitis, purulence, fever, chills, or elevated inflammatory markers such as white blood cells, ESR, or CRP
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single injection with follow-up up to 24 weeks
Participants receive either ketorolac or triamcinolone injections to the shoulder, elbow, wrist, or hand using a standard technique by the treating physician.
1 baseline visit and 2 follow-up visits at 6 and 24 weeks
Trial Site Locations
Total: 4 locations
1
Emory Saint Joseph's Hospital
Atlanta, Georgia, United States, 30308
Actively Recruiting
2
Emory University Orthopaedic and Spine Center
Atlanta, Georgia, United States, 30324
Actively Recruiting
3
12 Executive Park Drive
Atlanta, Georgia, United States, 30329
Actively Recruiting
4
Emory University Orthopaedic and Spine Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
Research Team
P
Paul A. Ghareeb, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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