Actively Recruiting

Phase 4
Age: 18Years +
All Genders
ID05292339

Single Blind Randomized Controlled Trial to Evaluate Ketorolac Injections for Upper Extremity Tendinopathy and Arthropathy

Led by Emory University · Updated on 2025-08-24

160

Participants Needed

4

Research Sites

N/A

Total Duration

On this page

Sponsors

E

Emory University

Lead Sponsor

A

American Association for Hand Surgery: AAHS

Collaborating Sponsor

AI-Summary

What this Trial Is About

Osteoarthritis and inflammatory conditions affecting the tendons and joints of the shoulder, elbow, hand, and wrist are common and can cause significant pain and disability. This research aims to evaluate and compare the effects of ketorolac and triamcinolone injections for treating tendinopathy or arthropathy in these upper extremity areas. These conditions often reduce strength and daily function, and current treatments focus on managing symptoms rather than curing the disease. Participants in this study will be randomly assigned to receive either a ketorolac injection, a non-steroidal anti-inflammatory drug that reduces inflammation, or a triamcinolone injection, a corticosteroid that decreases inflammation. Both injections will be given using standard techniques by the treating physician. The study lasts for 24 weeks, with an important follow-up visit scheduled 6 weeks after the injection to assess outcomes. During the study, participants will have their pain levels measured using a visual analog scale, along with assessments of function and strength through questionnaires and physical tests at baseline, 6 weeks, and 24 weeks. These include patient-reported outcome measures, hand function assessments, and grip strength tests. The study will monitor the effects of the injections to help understand how best to manage wrist and hand joint conditions conservatively.

CONDITIONS

Brief Title

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist
  • No prior surgical treatment for the condition
  • Diagnoses may include trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis
Not Eligible

You will not qualify if you...

  • Under 18 years of age
  • Prior triamcinolone or ketorolac injections within the past 6 months
  • Previous surgical treatment for the hand condition
  • Allergy or contraindication to triamcinolone or ketorolac injections
  • Active infection at the treatment site, including cellulitis, purulence, fever, chills, or elevated inflammatory markers such as white blood cells, ESR, or CRP

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Treatment

Duration - Single injection with follow-up up to 24 weeks

Participants receive either ketorolac or triamcinolone injections to the shoulder, elbow, wrist, or hand using a standard technique by the treating physician.

1 baseline visit and 2 follow-up visits at 6 and 24 weeks

Trial Site Locations

Total: 4 locations

1

Emory Saint Joseph's Hospital

Atlanta, Georgia, United States, 30308

Actively Recruiting

2

Emory University Orthopaedic and Spine Center

Atlanta, Georgia, United States, 30324

Actively Recruiting

3

12 Executive Park Drive

Atlanta, Georgia, United States, 30329

Actively Recruiting

4

Emory University Orthopaedic and Spine Hospital

Atlanta, Georgia, United States, 30329

Actively Recruiting

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Research Team

P

Paul A. Ghareeb, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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