Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT05292339

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Led by Emory University · Updated on 2025-08-24

160

Participants Needed

4

Research Sites

230 weeks

Total Duration

On this page

Sponsors

E

Emory University

Lead Sponsor

A

American Association for Hand Surgery: AAHS

Collaborating Sponsor

AI-Summary

What this Trial Is About

Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints. The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy. Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed.

CONDITIONS

Official Title

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 or older
  • Symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist
  • No prior surgical treatment for the affected condition
  • Diagnosed with conditions such as trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis
Not Eligible

You will not qualify if you...

  • Under 18 years of age
  • Prior triamcinolone or ketorolac injections within the last 6 months
  • Prior surgical treatment for hand condition
  • Allergy or contraindication to triamcinolone or ketorolac injections
  • Active infection at the treatment site, including cellulitis, purulence, fever, chills, or elevated inflammatory markers such as white blood cells, erythrocyte sedimentation rate, or C-reactive protein

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 4 locations

1

Emory Saint Joseph's Hospital

Atlanta, Georgia, United States, 30308

Actively Recruiting

2

Emory University Orthopaedic and Spine Center

Atlanta, Georgia, United States, 30324

Actively Recruiting

3

12 Executive Park Drive

Atlanta, Georgia, United States, 30329

Actively Recruiting

4

Emory University Orthopaedic and Spine Hospital

Atlanta, Georgia, United States, 30329

Actively Recruiting

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Research Team

P

Paul A. Ghareeb, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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