Actively Recruiting
KIdney aNd blooD prESsure ouTcomes in Childhood Cancer Survivors (CCS)
Led by The Hospital for Sick Children · Updated on 2024-04-17
500
Participants Needed
1
Research Sites
834 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Childhood cancer survivors (CCS) are at elevated risk of chronic health conditions. Chemotherapies can cause recurrent acute kidney injury which may progress to kidney fibrosis, chronic kidney disease (CKD) or hypertension (HTN). CCS surviving to adulthood are at ≥3 times the risk (vs. non-CCS) for CKD, HTN and lower quality of life. However, the timing of CKD and HTN onset in CCS completing cancer therapy in childhood remains unclear. Guidelines provide recommendations on managing post-cancer therapy effects in CCS, but they lack specificity on kidney testing content, frequency and complications. This discord is largely due to knowledge gaps on which CCS develop CKD or HTN after cancer therapy, when outcomes occur and their severity. Existing work has shown in select patients, CKD and HTN in CCS likely begins in the first 5 years post-cancer therapy and that the burden is significant. With robust data on CKD and HTN, international CCS follow-up guidelines can be optimized to include detailed and actionable recommendations on kidney and blood pressure monitoring and treatment.
CONDITIONS
Official Title
KIdney aNd blooD prESsure ouTcomes in Childhood Cancer Survivors (CCS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 3 years ± 6 months after therapy for first cancer
- Received high-risk therapy for first cancer, including alkylating agents, platinums, abdominal or total body radiation, high dose methotrexate, stem cell transplant, nephrectomy, or other therapies known to possibly cause late kidney and/or blood pressure effects
You will not qualify if you...
- Severe chronic kidney disease before cancer or previous kidney transplant
- Older than 19 years at 3 years after cancer therapy completion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Hospital For Sick Children
Toronto, Ontario, Canada, M5G 1E8
Actively Recruiting
Research Team
M
Michael Zappitelli, MD
CONTACT
Y
Yasmine Hejri-Rad, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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