Actively Recruiting
Kidney Graft Tolerance KTOL
Led by Nantes University Hospital · Updated on 2026-05-05
15
Participants Needed
1
Research Sites
170 weeks
Total Duration
On this page
Sponsors
N
Nantes University Hospital
Lead Sponsor
I
Institut National de la Santé Et de la Recherche Médicale, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Prospective experimental study using PBMC from a limited number of adult patients (15) treated at Nantes University Hospital for a kidney transplant from a related living donor. The study will be carried out on PBMC from both donors and recipients, collected during visits scheduled as part of the clinical management of the donor/recipient pair. The study will test the hypothesis that DP8α Tregs expressing CD73, whose frequency in blood increases stably after non-rejected kidney transplants, but not when patients have undergone or will subsequently undergo rejection, are enriched in donor-specific cells, which would be a strong argument in favor of a direct role for these Tregs in preventing transplant rejection, through their ability to inhibit immune responses directed against donor alloantigens.
CONDITIONS
Official Title
Kidney Graft Tolerance KTOL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult donor-recipient pair
- First or second kidney transplant from a related ABO-compatible living donor
- Body mass index (BMI) less than 35 for recipients
- Adult patients
- Patients weighing over 50 kilograms
You will not qualify if you...
- Donor and recipient ABO incompatibility
- Body mass index (BMI) greater than 35 for recipients
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nantes University Hospital
Nantes, Loire-Atlantique, France, 44093
Actively Recruiting
Research Team
C
Christophe MASSET, PH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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