Study of Salt Substitute to Protect Kidney Function After Kidney Tumor Surgery Randomized Trial Comparing Salt Substitute to Regular Salt in Adults

What this Trial Is About

Researchers are evaluating the use of salt substitutes to protect kidney function after surgery for kidney tumors in this open-label, randomized controlled trial. The study aims to determine if a salt substitute diet can improve estimated glomerular filtration rate eGFR compared to a regular salt diet. It also examines the safety, patient compliance, and feasibility of using salt substitutes in the diet of postoperative kidney tumor patients. Participants will be assigned to either a salt substitute group or a regular salt group. They will consume their assigned type of salt daily while adhering to WHO-recommended salt intake levels for one year. The study provides free salt substitutes in phases, with adherence checks at scheduled follow-ups. Telemedicine follow-up is planned at 9 months to support compliance. Non-adherence will lead to education or discontinuation from the study. Participants will undergo assessments at 1, 3, 6, and 12 months after surgery, including 24-hour urine tests at months 1 and 6 to monitor adherence. Researchers will regularly monitor blood electrolytes, eGFR, and other kidney function markers. They will record any adverse events or health changes. The primary outcome is eGFR at 12 months post-surgery, with secondary outcomes including eGFR decline rate, CKD progression, proteinuria progression, adverse events, and quality of life measured over the year-long follow-up.

Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery