Redefining the concept of residual renal function with kidney sodium MRI: a pilot study.
Sandrine Lemoine, Alireza Akbari, Gary Brahm...
https://pubmed.ncbi.nlm.nih.gov/38688870Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID05014178
Kidney Sodium Functional Imaging: Evaluation of Kidney Medullary Sodium Content Using 23Na MRI in Kidney Disease
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2025-02-12
200
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how the corticomedullary gradient in the kidneys, which helps concentrate urine and maintain body fluid balance in warm weather, may be altered in people with various kidney diseases. This study uses Sodium-23 Magnetic Resonance Imaging (MRI) to non-invasively measure the salt content in the kidneys. The goal is to better understand kidney function across a wide range of kidney conditions to improve management of chronic kidney disease and related disorders. Participants will undergo a Sodium-23 MRI scan of their kidneys during two visits lasting about two hours each. Before the MRI scan, blood pressure and heart rate will be measured, and participants will provide blood and urine samples. Those treated for kidney stones will also complete a 24-hour urine volume test prior to the scan. The study includes groups such as adults with chronic kidney disease, kidney transplants, dialysis, polycystic kidney disease, nephrolithiasis, and healthy controls. During the study visits, researchers will assess the cortico-medullary gradient through MRI and evaluate urinary osmolarity, renal function, kidney biopsy results, and other kidney-related conditions. The scans and tests aim to provide functional information about the kidneys. Participant involvement includes clinical assessments, sample collection, and imaging, with the total visit time averaging two hours. This observational study uses these measures to explore kidney medullary sodium content and its role in kidney disease.
CONDITIONS
Brief Title
Kidney Sodium Functional Imaging
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Healthy controls must not have kidney disease, heart failure, liver cirrhosis, or peripheral edema
- For chronic kidney disease participants, estimated GFR less than 90 mL/min/1.73m2
- For dialysis patients, more than 3 months of maintenance hemodialysis or peritoneal dialysis
You will not qualify if you...
- Pregnant, breastfeeding, or planning pregnancy
- Contraindications to MRI including inability to tolerate MRI due to size or claustrophobia
- Presence of implanted mechanical, electrical, or magnetic devices or metal in the body that cannot be removed, such as pacemakers, neurostimulators, aneurysm clips, surgical staples, or metallic fragments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo a sodium MRI scan of the kidneys along with blood pressure and heart rate measurements, blood work, and urine sample collection.
2 visits (in-person), including the MRI scan visit and a possible 24-hour urine collection the week before the MRI scan for some participants
Trial Site Locations
Total: 1 location
1
Victoria Hospital, London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
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Research Team
C
Christopher W McIntyre, MD
S
Sandrine Lemoine, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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