Actively Recruiting
Kidney Sodium Functional Imaging
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2025-02-12
200
Participants Needed
1
Research Sites
232 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The corticomedullary gradient is largely responsible for developing the gradients that are needed to concentrate urine (more solutes and less water). The ability of the kidneys to produce concentrated urine is a major determinant of the ability to survive the warm weather. When temperatures are high, we lose water through sweat, and so the kidneys retain water to maintain fluidity in the blood. The maintenance of a sodium (salt) gradient is required for urine concentration because increased medullary sodium concentration increases the reabsorption of water into the kidney, to be redistributed in the blood. The purpose of this study is to know if the corticomedullary gradient is altered in patients across a wide spectrum of kidney disease using sodium Magnetic Resonance Imaging (MRI), a machine that takes pictures and measures the salt content in the kidneys. 23Na kidney MRI, will provide functional MR of the kidney as a non-invasive tool to describe medullary function to improve management of chronic and kidney disease.
CONDITIONS
Official Title
Kidney Sodium Functional Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Healthy controls must have no kidney disease, heart failure, liver cirrhosis, or peripheral edema
- CKD stages 1-5 with estimated GFR less than 90 mL/min/1.73m²
- Patients on maintenance hemodialysis or peritoneal dialysis for more than 3 months
You will not qualify if you...
- Pregnant, breastfeeding, or planning pregnancy
- Contraindications to MRI
- Unable to tolerate MRI due to size or claustrophobia
- Presence of implanted mechanical, electrical, or magnetic devices or metal in the body that cannot be removed, including pacemakers, neurostimulators, insulin pumps, aneurysm clips, bioprosthesis, artificial limbs, metallic fragments, tattoos, shunts, surgical staples, or ear implants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Victoria Hospital, London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
Research Team
C
Christopher W McIntyre, MD
CONTACT
S
Sandrine Lemoine, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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