Study of Inflammation and Insulin Resistance in Adults with Calcium Kidney Stones and Healthy Controls

What this Trial Is About

This observational study investigates the links between kidney stones, insulin resistance, and inflammation. Researchers believe that people who form calcium kidney stones and have insulin resistance may have higher levels of inflammation due to increased visceral fat around the abdominal organs. The study will include 20 people with a history of calcium kidney stones but no diabetes, and 20 healthy people without kidney stones, to explore these relationships. Participants will first stop taking vitamin C, multivitamins, calcium supplements, and diuretics for one week before the study visit. They will also complete a 24-hour urine collection and a food questionnaire at home. On the study day, participants will visit the University of Chicagos Clinical Research Center fasting, where they will undergo measurements including height, weight, waist and neck circumference, a DEXA scan to assess visceral fat and bone density, and provide timed urine and blood samples. Blood pressure will be measured and kidney stone history reviewed during the visit. Samples will be analyzed for markers related to kidney stone risk, insulin resistance, inflammation, and metabolic factors. Throughout the study, participants will remain fasting until all samples are collected, with water freely allowed. Blood and urine samples will be tested for various chemicals and markers, and some samples will be stored for future research. The main outcomes include comparing visceral fat and inflammatory marker levels between stone formers with insulin resistance, those without, and healthy controls. The study aims to better understand how kidney stones relate to metabolic health and inflammation, potentially helping to identify those at risk earlier and inform preventive treatments.

Kidney Stone Inflammation