Actively Recruiting
KINETIC Kidney Transplant Improvement Through New Exercise Training to Increase Capacity
Led by University of Pennsylvania · Updated on 2026-05-06
60
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to find out if a home-based exercise program can be safely and effectively used to improve physical activity and physical function in adults aged 60 and older who are waiting for a kidney transplant. The study focuses on whether this remote exercise approach can be delivered successfully, if participants follow the program and wear an activity tracker as requested, and if the program is safe and well tolerated. It compares usual pre-transplant care with and without the addition of an online exercise program. Participants are randomly assigned to one of two groups. One group continues with usual care and wears a physical activity tracker to measure daily steps. The other group receives usual care plus access to a 12-week, home-based exercise prehabilitation program delivered online, which includes live and on-demand exercise classes focusing on light-to-moderate aerobic and resistance exercises. Participants in the exercise group receive reminders and feedback during the first 12 weeks, followed by another 12 weeks without reminders. During the study, all participants wear a wrist activity tracker and complete a one-week baseline period before randomization. They will answer health and activity questionnaires, and researchers will collect data on physical activity, physical function, safety events, and participant experiences. The study measures include enrollment, retention, adherence, adverse events, and changes in physical function and quality of life over the course of the intervention and follow-up periods.
CONDITIONS
Brief Title
Kidney Transplant Improvement Through New Exercise Training to Increase Capacity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be at least 60 years old
- Receive transplant care at Penn Medicine
- Be on the kidney transplant waiting list
- Speak and understand English
- Be able to walk independently
- Have at least one physical function limitation or one frailty metric
- Have access to an internet-connected device capable of downloading applications
- Be able to provide written informed consent
- Be medically cleared via the Physical Activity Readiness Questionnaire (PARQ) or written medical clearance
You will not qualify if you...
- Had a myocardial infarction or stroke within the last 3 months
- Unable to self-monitor with study devices (e.g., due to dementia)
- Not cleared to exercise by PARQ or medical clearance
- Currently participating in another physical activity study
- Have any other reason that may prevent completion of the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (virtual or in-person) for Physical Activity Readiness Questionnaire (PAR-Q) and medical clearance if needed
Duration - 1 week
Participants complete a one-week baseline run-in period during which physical activity data are collected using a wearable activity tracker to establish baseline step counts prior to randomization.
Daily activity tracking at home using wearable device
Duration - 12 weeks
Participants are randomized to either usual care with a wearable activity tracker or a 12-week, home-based exercise prehabilitation program with a wearable activity tracker and access to an online exercise platform. The exercise program includes live and on-demand classes focusing on light-to-moderate intensity aerobic and resistance exercises, with at least two exercise sessions per week. The intervention is delivered remotely with a brief virtual orientation and ongoing reminders and feedback for the intervention group.
Virtual orientation and ongoing remote exercise sessions and monitoring; continuous wearing of activity tracker
Duration - Up to 13 weeks after intervention
After the 12-week intervention period, participants are asked to continue their exercise program without study reminders or feedback. Outcomes related to physical function, quality of life, and other health measures are assessed at 13 and 25 weeks relative to baseline.
Assessments at approximately 13 and 25 weeks after baseline
Trial Site Locations
Total: 1 location
1
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
S
Sarah Schrauben, MD, MSCE
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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