Actively Recruiting
Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Led by Johns Hopkins University · Updated on 2025-06-15
200
Participants Needed
13
Research Sites
275 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
CONDITIONS
Official Title
Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant meets local criteria for kidney transplant.
- Participant is able to understand and provide informed consent.
- Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
- Participant is 18 years or older.
- HIV-1 RNA less than 50 copies/mL. Viral blips between 50-400 copies allowed if no consecutive measurements above 200 copies/mL.
- Participant is not suffering from significant wasting related to HIV disease (e.g., body mass index less than 21).
You will not qualify if you...
- Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis lasting more than 1 month, or primary central nervous system (CNS) lymphoma.
- Participant is pregnant or breastfeeding.
- Past or current medical problems or findings that may pose additional risks, interfere with study compliance, or affect data quality as determined by the investigator.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Not Yet Recruiting
2
University of California, Los Angeles
Los Angeles, California, United States, 90095
Not Yet Recruiting
3
University of California, San Diego
San Diego, California, United States, 92037
Not Yet Recruiting
4
University of California, San Francisco
San Francisco, California, United States, 94143
Not Yet Recruiting
5
Rush University Medical Center
Chicago, Illinois, United States, 60612
Not Yet Recruiting
6
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
Not Yet Recruiting
7
Johns Hopkins University
Baltimore, Maryland, United States, 21205
Actively Recruiting
8
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Not Yet Recruiting
9
New York University
New York, New York, United States, 10016
Not Yet Recruiting
10
Icahn School of Medicine at Mt. Sinai
New York, New York, United States, 10029
Not Yet Recruiting
11
Columbia University
New York, New York, United States, 10032
Not Yet Recruiting
12
Weill Cornell Medical Center
New York, New York, United States, 10065
Not Yet Recruiting
13
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Not Yet Recruiting
Research Team
C
Christine Durand, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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