Actively Recruiting
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Led by Beth Israel Deaconess Medical Center · Updated on 2026-02-05
28
Participants Needed
2
Research Sites
122 weeks
Total Duration
On this page
Sponsors
B
Beth Israel Deaconess Medical Center
Lead Sponsor
B
Boston University Charles River Campus
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?
CONDITIONS
Official Title
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteer
- Any race
- Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
- Urine albumin/creatinine ratio less than 30mg/g
- Nonsmoker
- No regular dietary supplements, particularly vitamin B3
- Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min
You will not qualify if you...
- Medical condition preventing safe participation in exercise during heat
- Allergy to Vitamin B3
- Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
2
Boston University
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
N
Nathan H Raines, MD MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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