Comparing High-Intensity Laser Therapy and Standard Physical Therapy for Knee Osteoarthritis in Adults Aged 40 to 75

What this Trial Is About

Researchers are evaluating the effectiveness and safety of High-Intensity Laser Therapy HILT compared to conventional physical therapy in adults with knee osteoarthritis, a condition causing pain, stiffness, and reduced mobility. This trial aims to see if HILT combined with exercises offers better pain relief and joint function improvement than standard physical therapy combined with the same exercises. The study will recruit 100 patients diagnosed with knee osteoarthritis based on recognized criteria. Participants will be randomly divided into two groups. One group will receive HILT using a four-wavelength laser system with specific frequencies and modes designed for deep tissue penetration, along with a standardized exercise program. The other group will receive standard physical therapy modalities such as therapeutic ultrasound or TENS combined with the same exercise program. Treatments will be conducted at specialized rheumatology and rehabilitation centers, with outcomes assessed at multiple time points. During the study, participants will undergo evaluations of pain levels using scales like WOMAC and VAS, joint function assessments, and MRI scans to observe structural changes in the knee. Laboratory tests will measure inflammation markers, cartilage metabolism genes, and oxidative stress before and after treatment. The main outcome focuses on pain intensity changes after four weeks, with additional assessments at eight weeks. The total participation period and follow-up details are included to monitor safety and effectiveness.

Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities