Actively Recruiting
Knee Osteoarthritis Rehabilitation Through Rotational Inertia
Led by University of Colorado, Denver · Updated on 2026-02-20
60
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
NIH/NCATS Colorado CTSA Grant Number T32TR004367
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods. The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail. The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
CONDITIONS
Official Title
Knee Osteoarthritis Rehabilitation Through Rotational Inertia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 40 to 70 years
- Radiographic confirmation of knee osteoarthritis with Kellgren-Lawrence Grade 2 or 3
- Able to walk independently, assistive devices allowed
- For healthy controls: Ages 40 to 70 years
- No radiographic evidence of knee osteoarthritis (Kellgren-Lawrence Grade 0 or 1)
- No frequent knee pain
- No history of knee surgery, significant knee injury, or diagnosed knee conditions such as patellofemoral pain syndrome or bursitis
You will not qualify if you...
- Uncontrolled hypertension or other cardiovascular diseases
- Musculoskeletal conditions preventing physical testing
- Neurological muscle weakness such as from stroke or spinal cord injury
- Body mass index over 34.9 kg/m²
- Hospitalization within the past 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado, Denver
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
K
Katie Boncella, MS
CONTACT
M
Michael Harris-Love, PT, MPT, DSc, FGSA, FAPTA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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