Actively Recruiting

Phase Not Applicable
Age: 40Years - 70Years
All Genders
Healthy Volunteers
NCT07424352

Knee Osteoarthritis Rehabilitation Through Rotational Inertia

Led by University of Colorado, Denver · Updated on 2026-02-20

60

Participants Needed

1

Research Sites

197 weeks

Total Duration

On this page

Sponsors

U

University of Colorado, Denver

Lead Sponsor

N

NIH/NCATS Colorado CTSA Grant Number T32TR004367

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods. The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail. The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.

CONDITIONS

Official Title

Knee Osteoarthritis Rehabilitation Through Rotational Inertia

Who Can Participate

Age: 40Years - 70Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Ages 40 to 70 years
  • Radiographic confirmation of knee osteoarthritis with Kellgren-Lawrence Grade 2 or 3
  • Able to walk independently, assistive devices allowed
  • For healthy controls: Ages 40 to 70 years
  • No radiographic evidence of knee osteoarthritis (Kellgren-Lawrence Grade 0 or 1)
  • No frequent knee pain
  • No history of knee surgery, significant knee injury, or diagnosed knee conditions such as patellofemoral pain syndrome or bursitis
Not Eligible

You will not qualify if you...

  • Uncontrolled hypertension or other cardiovascular diseases
  • Musculoskeletal conditions preventing physical testing
  • Neurological muscle weakness such as from stroke or spinal cord injury
  • Body mass index over 34.9 kg/m²
  • Hospitalization within the past 3 months

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Colorado, Denver

Aurora, Colorado, United States, 80045

Actively Recruiting

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Research Team

K

Katie Boncella, MS

CONTACT

M

Michael Harris-Love, PT, MPT, DSc, FGSA, FAPTA

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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