Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice.
Gabriela V Moreira, Layanne C C Araujo, Gilson M Murata...
https://pubmed.ncbi.nlm.nih.gov/36095960Actively Recruiting
Phase Not Applicable
Age: 18Years - 60Years
All Genders
ID06759324
Study of Live vs. Pasteurized Kombucha Effects on Gut Health, Metabolism, and Liver Function in Overweight and Class 1 Obesity
Led by Associação Centro de Apoio Tecnológico Agro Alimentar · Updated on 2025-01-06
33
Participants Needed
2
Research Sites
20 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of kombucha, a fermented tea beverage, on individuals who are overweight or have class 1 obesity. The study focuses on how kombucha impacts gut microbiota composition, metabolic parameters such as glucose and insulin levels, lipid profiles, and liver function. Previous animal studies suggested potential benefits, but this clinical study aims to provide stronger evidence in humans through a randomized controlled pilot trial. Participants will be randomly assigned to one of three groups: one group will consume 33 cl of live (non-pasteurized, non-filtered) kombucha daily, another will consume 33 cl of pasteurized kombucha daily, and the control group will receive 33 cl of sparkling water daily. Each intervention lasts for 4 weeks (28 days), allowing comparison between the effects of live versus pasteurized kombucha and the control on health markers. During the 4-week study, participants will provide fecal samples to analyze gut microbiota changes and undergo measurements of fasting glucose, insulin levels, insulin resistance (HOMA-IR), and lipid profiles. The study will monitor these outcomes to evaluate the metabolic and microbiome effects of kombucha consumption. Participants must comply with the study protocol and attend scheduled assessments throughout the study period.
CONDITIONS
Official Title
Kombucha in Overweight and Obese: Live Vs. Pasteurized Effects on Microbiota, Metabolism, and Liver Function
Who Can Participate
Age: 18Years - 60Years
All Genders
Eligibility Criteria
You may qualify if you...
- Individuals aged between 18 and 60 years
- Body Mass Index (BMI) between 25 kg/m² and 34.9 kg/m²
- Both biological sexes eligible
- Willingness to comply with the study protocol and sign informed consent
You will not qualify if you...
- Sensitivity to kombucha
- Consumption of kombucha or other fermented products within 3 weeks before or during the study
- Antibiotic use within 6 months before the study
- Use of probiotics, prebiotics, fibers, or laxatives within 6 weeks before recruitment
- Following specific dietary regimens or treatments (e.g., vegan, high protein)
- Excessive alcohol consumption or smoking
- Diagnosis of gastrointestinal, hormonal, thyroid, autoimmune, psychiatric diseases, or diabetes types 1 or 2
- Use of proton pump inhibitors, antidiabetic drugs, insulin, or statins
- Presence of insulin sensitivity
- Pregnant or lactating women
- Tooth sensitivity
- Participation in another clinical trial within the last 3 months
AI-Screening
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1
2
3
Trial Site Locations
Total: 2 locations
1
Centro de Apoio Tecnológico Agro Alimentar (CATAA)
Castelo Branco, Castelo Branco District, Portugal, 6000-459
Actively Recruiting
2
Centro de Apoio Tecnológico Agro Alimentar (CATAA) (facilities temporarily provided by the Affidea clinical analysis center)
Covilha, Portugal, 6200-077
Actively Recruiting
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Research Team
I
Inês Brandão, PhD
F
Filomena Pereira, Nutritionist
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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