Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research

What this Trial Is About

Glomerulonephritis (GN), including conditions like Minimal Change Disease, Focal Segmental Glomerulosclerosis, Membranous Nephropathy, and IgA Nephropathy, often leads to kidney problems and places a heavy burden on individuals and society. This research focuses on understanding GN better by using clinical and pathological data along with advanced molecular and genomic analysis from kidney biopsy samples to support future personalized medicine approaches in nephrology. A multi-center network in Korea, called KORNERSTONE, was created to collect and study this information. The study involves patients with biopsy-confirmed GN who are scheduled for a kidney biopsy for clinical reasons. Along with the biopsy, additional kidney tissue samples and patient-derived materials will be collected with consent. The study collects various data including blood and urine tests, imaging results, pathology reports, treatment details, and quality of life questionnaires for both adults and children. The collected biological and clinical data are stored in a digital, web-accessible database to support ongoing and future research. Participants will be observed over time with data collected on health outcomes such as death, kidney function deterioration, clinical improvements, and other health events like infections, cardiovascular issues, and hospital visits over a 60-month period. Researchers monitor these outcomes alongside treatment and lifestyle information. The study aims to build a long-term resource to better understand GN biology and patient prognosis, with participant involvement including clinical evaluations, laboratory testing, imaging, and patient surveys throughout the follow-up period.

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