Actively Recruiting
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2 (KBASE2)
Led by Seoul National University Hospital · Updated on 2024-05-03
640
Participants Needed
2
Research Sites
230 weeks
Total Duration
On this page
Sponsors
S
Seoul National University Hospital
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The KBASE2 is the second phase of the KBASE project, which consists of roll-over participants from the first phase of the KBASE as well as newly enrolled participants with varying degrees of cognitive functions (e.g. individuals with normal cognition, mild cognitive impairment, or AD dementia). In addition to the aims of the first phase of the KBASE, the KBASE2 will focus on new data collection and integrative analysis of the rich structural, functional, and molecular neuroimaging data in relation to whole genome sequencing and other -omics. Network analysis of disruption in brain connectivity in relation to clinical status and AD biomarker profiles also will be conducted.
CONDITIONS
Official Title
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2 (KBASE2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 55 to 90 with Alzheimer's disease with Clinical Dementia Rating (CDR) of 0.5 or 1
- Participants aged 55 to 90 with amnestic mild cognitive impairment with CDR of 0.5 and cognitive concerns
- Participants aged 55 to 90 who are elderly normal controls with CDR of 0 and a contactable informant
- Participants aged 20 to 54 who are young normal controls with CDR of 0
- Study partner or caregiver available to accompany participants to all visits
- Written informed consent provided
You will not qualify if you...
- Past or present major psychiatric illness such as schizophrenia, bipolar disorder, alcohol or substance abuse, or delirium
- Significant neurological or medical condition affecting mental state
- Contraindications for MRI scan such as pacemaker or claustrophobia
- Illiteracy
- Significant visual or hearing difficulties
- Currently taking an investigational drug
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
2
SMG-SNU Boramae Medical Center
Seoul, South Korea
Actively Recruiting
Research Team
D
Dong young Lee, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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