Actively Recruiting
Korean Prospective Upper Tract Urothelial Carcinoma Cohort
Led by Samsung Medical Center · Updated on 2026-03-05
300
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, prospective, non-interventional observational cohort study designed to establish a structured recurrence monitoring platform in Korean patients with high-grade non-metastatic upper tract urothelial carcinoma (UTUC). Eligible adult patients scheduled to receive neoadjuvant chemotherapy followed by radical nephroureterectomy will undergo circulating tumor DNA (ctDNA) sampling prior to chemotherapy initiation and once between 1-6 months after surgery. Clinical, imaging, pathological, and longitudinal follow-up data will be prospectively collected to enable long-term monitoring of recurrence and survival outcomes. The primary objective is to establish a prospective cohort integrating clinical and molecular data to support future translational research and recurrence prediction modeling in UTUC.
CONDITIONS
Official Title
Korean Prospective Upper Tract Urothelial Carcinoma Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 19 years or older
- Histologically confirmed high-grade upper tract urothelial carcinoma (renal pelvis and/or ureter)
- Clinical stage cT2-T4, cN0-1, M0 disease
- Planned neoadjuvant chemotherapy followed by radical nephroureterectomy
- ECOG performance status of 0 or 1
- Adequate blood, liver, and kidney function
- Able to provide written informed consent
You will not qualify if you...
- Evidence of distant metastasis (M1)
- Contraindication to cisplatin-based chemotherapy
- Uncontrolled infection or severe comorbid medical condition
- Pregnancy or breastfeeding
- Any condition that makes participation inappropriate as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
Research Team
J
Jiwoong Yu, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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