Observational Study to Monitor Recurrence in Korean Adults with High-Grade Upper Tract Urothelial Carcinoma Receiving Neoadjuvant Chemotherapy and Surgery

What this Trial Is About

Researchers are conducting a single-center, prospective, non-interventional observational cohort study to monitor recurrence in Korean patients with high-grade non-metastatic upper tract urothelial carcinoma UTUC. This study aims to combine clinical and molecular data to support future research and develop models to predict recurrence and survival outcomes in UTUC. The study focuses on adult patients scheduled for neoadjuvant chemotherapy followed by radical nephroureterectomy, addressing a gap in prospective data particularly in Asian populations. Participants will provide peripheral blood samples for circulating tumor DNA ctDNA analysis before starting neoadjuvant chemotherapy and once between one to six months after surgery. The study does not involve investigational drugs all treatments and evaluations follow standard clinical practice. Clinical, imaging, pathological, and longitudinal follow-up data will be collected to monitor recurrence and survival. Participants will be followed for up to five years, with data collected on recurrence-free survival, overall survival, cancer-specific survival, and ctDNA positivity rates. Researchers will gather demographic, clinical, treatment, and outcome data, including imaging and pathology results, to support long-term monitoring and future precision oncology research. The study allows ongoing observation without intervention beyond standard care.

Korean Prospective Upper Tract Urothelial Carcinoma Cohort