Actively Recruiting
Kratom Use Disorder Management Using Clonidine and/or Buprenorphine
Led by Salem Anaesthesia Pain Clinic · Updated on 2025-01-27
50
Participants Needed
1
Research Sites
391 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Kratom is used for stimulant, analgesic, anxiolytic, and sedative effects. There is inadequate knowledge about Kratom addiction. Kratom withdrawal may be treated like opioid withdrawal. Prospective observational crossover study of consenting adults who are undergoing Kratom withdrawal management. On alternate weeks, each patient receives treatment using Buprenorphine 5cmg/hr patch; or Clonidine tablet 0.1mg 4hourly; or combined Clonidine tablet 0.1mg 4hourly + Buprenorphine 5cmg/hr patch. Each patient will undergo treatment for 12 weeks. Patients will use Subjective Opiate Withdrawal Scale (SOWS) to collect data on daily basis. SOWS is a patient-administered tool that is used to record the severity and presence of opiate withdrawal. The physician will also use Clinical Opiate Withdrawal Scale (COWS) to collect data on weekly basis. COWS is a clinician-administered tool that is used to record the signs of opiate withdrawal. A change in the COWS and SOWS scores by 6-points is considered significant.
CONDITIONS
Official Title
Kratom Use Disorder Management Using Clonidine and/or Buprenorphine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients
- Diagnosis of Kratom dependence
- Experiencing Kratom withdrawal syndrome
- Undergoing Kratom withdrawal therapy
- Good compliance with treatment
- Able to reliably complete Subjective Opiate Withdrawal Scale (SOWS) diary
- Able to reliably complete Clinical Opiate Withdrawal Scale (COWS) diary
- Provided informed consent for diary review
- Provided consent for clinical record quality assurance review
You will not qualify if you...
- Poor compliance with treatment
- Cognitive disorder
- Unable to provide informed consent
- Major neuropsychiatric disorder
- Unreliable diary completion
- Cannabis use
- Excessive alcohol intake
- Previous adverse or allergic reactions to clonidine
- Previous adverse or allergic reactions to buprenorphine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Salem Anaesthesia Pain Clinic
Surrey, British Columbia, Canada, V3S 7J1
Actively Recruiting
Research Team
O
Olu Bamgbade, MD,FRCPC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here