Long-Term Follow-Up of Kuwaiti Adults for Diabetes and Metabolic Health Tracking Progression of Prediabetes and Diabetes Complications

What this Trial Is About

Researchers are conducting a follow-up study on the Kuwait Diabetes Epidemiology Program KDEP to better understand the risk factors leading to the onset of prediabetes and progression to type 2 diabetes T2D and related complications. This study focuses on the Kuwaiti population, a group with a high prevalence of obesity, diabetes, and metabolic disorders, and aims to gather detailed physiological, genetic, biochemical, and environmental data. The study also includes family members of original participants to explore familial patterns in diabetes risk. Participants from the original KDEP cohort who were non-diabetic, as well as other high-risk individuals, will be included. The study involves assessing participants with oral glucose tolerance tests OGTT and other detailed biochemical and molecular evaluations to identify factors associated with the development of diabetes and its vascular complications. A subset of around 250 participants will receive additional specialized testing such as hyperglycemia clamp and euglycemic clamp procedures. During the study, participants will be monitored over 4 to 7 years to determine the incidence of diabetes and prediabetes, as well as microvascular and macrovascular complications. Researchers will collect data through blood glucose measurements, HbA1C levels, and detailed clinical evaluations. The study aims to support the development of prevention strategies and health promotion programs in Kuwait by providing data on diabetes progression and associated risk factors. The total participation duration may extend up to five years for outcome assessment.

Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program