Actively Recruiting
L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients
Led by The University of Texas at Arlington · Updated on 2025-03-03
15
Participants Needed
2
Research Sites
465 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. A potential signal driving sympathetic nerve activity (SNA) involves accumulation of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). ADMA is elevated in CKD and is a strong, independent predictor of future cardiovascular events in these patients. . The goal of this study is to determine whether overcoming the accumulation of endogenous ADMA with acute L-arginine infusion reduces SNA in CKD patients.
CONDITIONS
Official Title
L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- CKD patients classified as Stage 3 and 4 with estimated glomerular filtration rate (GFR) between 15 and 59 mL/min/1.73 m2
- Men and women aged 35 to 75 years
You will not qualify if you...
- History of myocardial infarction
- Heart failure
- Anemia with hemoglobin less than 8 g/dl
- Current cancer treatment
- Previous organ transplantation
- Use of immunosuppressant therapy
- HIV infection
- Pregnancy or breastfeeding
- Current tobacco use
- Taking menopausal drugs such as estradiol
- Treatment for diabetic neuropathy
- Resting heart rate equal to or greater than 100 bpm
- Systolic blood pressure less than or equal to 90 mmHg
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University of Delaware
Newark, Delaware, United States, 19716
Actively Recruiting
2
UT Southwestern
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
P
Paul J Fadel, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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