Actively Recruiting
L-Carnitine Protective Effect in Nephrotoxicity
Led by Tanta University · Updated on 2025-08-12
46
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess the possible reno-protective effect of L-carnitine against cisplatin-induced nephrotoxicity in patients receiving cisplatin-based chemotherapy. The main question it aims to answer is: Does L-carnitine have the ability to protect the kidney against cisplatin-induced nephrotoxicity?
CONDITIONS
Official Title
L-Carnitine Protective Effect in Nephrotoxicity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients
- Newly diagnosed with cancer and scheduled for cisplatin-based chemotherapy
- Aged between 18 and 75 years
- No serious heart or lung conditions that affect study participation
- Creatinine clearance above 50 mL/min/1.73 m²
- Scheduled to receive at least 3 cycles of cisplatin
- No previous kidney diseases, including acute nephropathy or renal failure
You will not qualify if you...
- Pregnancy or breastfeeding
- Metastasis to the central nervous system
- Psychiatric disorders
- Prior treatment with platinum-based chemotherapy
- Allergy to cisplatin, carboplatin, or other platinum drugs
- Active infection or signs of sepsis
- Acute kidney failure or kidney surgery within the last 3 months
- Unfit for cisplatin due to kidney problems, hearing loss, or heart muscle disease
- History of or current treatment with kidney-damaging drugs
- Taking antioxidant supplements like Vitamins C or E
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Menoufia Clinical Oncology Department, Menoufia University.
Shibīn al Kawm, Egypt
Actively Recruiting
Research Team
F
Fatma M Eweda, Master
CONTACT
F
Fatma M Eweda
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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