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Study Comparing Different Bowel Preparation Methods Before Colonoscopy Using 4-L Split-dose Polyethylene Glycol with Bisacodyl and Docusate Sodium Versus 2-L Split-dose Polyethylene Glycol with Oral Simethicone Versus Conventional 2-L Polyethylene Glycol
Led by Tanta University · Updated on 2026-01-09
450
Participants Needed
1
Research Sites
3 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating the safety, compliance, and effectiveness of different bowel preparation methods before colonoscopy. This randomized controlled trial compares three regimens a 4-liter split-dose polyethylene glycol combined with bisacodyl and docusate sodium, a 2-liter split-dose polyethylene glycol plus oral simethicone, and a conventional 2-liter split-dose polyethylene glycol alone. The study aims to assess how well these methods prepare the bowel and their tolerability for patients undergoing colonoscopy. Participants will be randomly assigned to one of three groups. One group receives four sachets of polyethylene glycol mixed in 4 liters of water over 8 hours starting at 9 a.m., along with bisacodyl and docusate sodium tablets. The second group receives two sachets of polyethylene glycol mixed in 2 liters of water over 4 hours from 9 a.m. plus oral simethicone tablets. The third group receives two sachets of polyethylene glycol in 2 liters of water over 4 hours starting at 9 a.m. without simethicone. Colonoscopy is performed 24 hours after starting the preparation. During the study, participants will undergo medical history taking, clinical exams, laboratory tests, and colonoscopy. Researchers will evaluate the quality of bowel preparation using the Aronchick scale, monitor adverse events, and collect patient feedback on ease of use, tolerability, and willingness to repeat the same regimen in the future. The primary outcome is completing a full colonoscopy successfully, with safety and tolerability tracked throughout the study period, which lasts about one year.
CONDITIONS
Brief Title
4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy
Research Team
R
Rania M Elkafoury, MD
N
Nabila A Elgazzar, MD
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