Actively Recruiting
L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance
Led by City of Hope Medical Center · Updated on 2026-05-08
50
Participants Needed
4
Research Sites
63 weeks
Total Duration
On this page
Sponsors
C
City of Hope Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial tests the feasibility, best dose, and effectiveness of L-theanine for supporting relaxation and mood among cancer patients in surveillance. L-theanine is a substance found in the leaves of green tea with potential to enhance mental health and well-being. It works by increasing certain chemicals within the body that have been associated with stress reduction, mood stabilization, and improved cognitive performance.
CONDITIONS
Official Title
L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided documented informed consent and assent when appropriate
- Willing to comply with study interventions and follow-up assessments
- Age 18 years or older
- Able to read and understand English or Spanish for questionnaires
- Cancer patient who completed treatment and has been in surveillance for at least 6 months
- No use of herbs or supplements in the past 30 days
- Anxiety score greater than 3 on Visual Analog Scale - Anxiety
- No changes to psychiatric medications within the past 60 days
- Women of childbearing potential with negative pregnancy test
- Agreement by participants of childbearing potential to use effective birth control or abstain during the study and for 1 month after last dose
You will not qualify if you...
- Concurrent use of other alternative medicines including herbal agents and high-dose vitamins/minerals unless correcting documented insufficiency
- Receiving chemotherapy, radiation, biological therapy, immunotherapy, or systemic treatment except stable hormonal therapy for at least 60 days
- Taking bortezomib
- Enrolled in other clinical trials interfering with this study
- History of allergic reactions to similar compounds
- Active or unstable psychiatric conditions, depressive/bi-polar disorders, anxiety, psychosis, or substance use interfering with participation
- Chronically unstable or low blood pressure
- Diagnosis of Gilbert's disease
- Pregnant or breastfeeding females
- Any condition judged by the investigator to contraindicate participation due to safety
- Inability to comply with study procedures as judged by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
2
City of Hope Seacliff
Huntington Beach, California, United States, 92648
Not Yet Recruiting
3
City of Hope at Irvine Lennar
Irvine, California, United States, 92618
Not Yet Recruiting
4
City of Hope at Irvine Sand Canyon
Irvine, California, United States, 92618
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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