Comparative Study of Labetalol Versus Dexmedetomidine Infusion in Hypotensive Anesthesia for Ear, Nose, and Throat Surgeries

What this Trial Is About

This research aims to compare the effects of Labetalol infusion and Dexmedetomidine infusion in creating hypotensive anesthesia during ear, nose, and throat surgeries. Hypotensive anesthesia involves deliberately lowering blood pressure to improve the surgical field, ease the operation, and reduce surgery time. Labetalol is an anti-hypertensive drug that blocks certain adrenergic receptors, while Dexmedetomidine is a selective alpha2 adrenergic agonist that helps lower blood pressure and heart rate during surgery. The study involves administering either Labetalol or Dexmedetomidine through infusion to patients undergoing ear, nose, and throat surgeries to induce hypotension. Both drugs will be evaluated for their ability to maintain controlled low blood pressure during the procedure. The comparison focuses on their roles in hypotensive anesthesia to determine their effectiveness and safety profiles. Participants will be monitored for changes in mean arterial blood pressure before anesthesia induction and every 15 minutes during the hypotensive anesthesia. The study tracks blood pressure over 12 months to assess the drugs' effects throughout the surgical period. Safety and tolerability will be observed, and patient responses to each drug infusion will be carefully recorded to inform outcomes.

Labetalol Infusion and Dexmedetomidine Infusion in Hypotensive Anesthesia