Actively Recruiting
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Led by Università Vita-Salute San Raffaele · Updated on 2025-08-12
110
Participants Needed
4
Research Sites
187 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Barotrauma (pneumothorax, pneumomediastinum) is a well-described complication of Acute Respiratory Distress Syndrome (ARDS), especially in patients with coronavirus disease 2019 (COVID-19) (16.1% in COVID-19, and about 6% in non-COVID-19 ARDS). Macklin effect was recently discovered by our group as an accurate radiological predictor of barotrauma in COVID-19 ARDS; the Investigators also found that density histograms automatically extracted from chest CT images provide a reliable insight into lung composition . Since lung frailty is a major issue also in non-COVID-19 ARDS, the Investigators want to confirm the predictive role of Macklin effect also in this setting. In addition, the Investigators aim to explore inflammatory profiling to decipher different biological aspects of the same clinical issue. Finally, the Investigators want to develop a specific management algorithm for patients diagnosed, according to our findings, with a specific ARDS sub phenotype characterized by increased lung frailty
CONDITIONS
Official Title
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical and radiological signs of ARDS, according to Berlin criteria, requiring ICU admission
- Signed informed consent obtained
- At least one chest CT scan available during hospital stay
You will not qualify if you...
- Poor quality imaging due to motion or respiratory artifacts
AI-Screening
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Trial Site Locations
Total: 4 locations
1
A.O.U. di Cagliari
Cagliari, Italy
Not Yet Recruiting
2
IRCCS San Raffaele Scientific Institute
Milan, Italy, 20132
Actively Recruiting
3
A.O.U. Pisana
Pisa, Italy
Not Yet Recruiting
4
Ospedale San Carlo
Potenza, Italy
Not Yet Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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