Actively Recruiting
LaCE (Lactobacillus Paracasei LPB27 On Early Childhood Eczema)
Led by The University of New South Wales · Updated on 2025-06-03
100
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
Sponsors
T
The University of New South Wales
Lead Sponsor
E
Evolution Health Pty Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
The LaCE study is a double-blind, randomised, placebo-controlled trial examining the effectiveness of the probiotic Lactobacillus paracasei LPB27 in treating eczema in young children.
CONDITIONS
Official Title
LaCE (Lactobacillus Paracasei LPB27 On Early Childhood Eczema)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 3 months and 3 years old
- Clinical diagnosis of eczema (atopic dermatitis) by a pediatric dermatologist or immunologist
- Eczema severity with Investigator Global Assessment (IGA) score of 1 to 3 (almost clear, mild, moderate)
- SCORAD score greater than 8.7
- Willingness and ability to follow study protocol requirements
You will not qualify if you...
- Use of systemic immunosuppression or biologic agents (withdrawn if started during study)
- Breastfeeding mothers taking probiotics who are unwilling to stop
- Child currently taking probiotics or probiotic-containing formulas and parents unwilling to stop for the study duration
- Eczema complicated by active skin infections (e.g., impetigo, cellulitis, eczema herpeticum) unless resolved
- Child currently on oral or IV antibiotics (washout allowed after completion)
- Immunodeficiency disorders
- Chronic gastrointestinal diseases such as inflammatory bowel disease, short gut syndrome, cystic fibrosis
- Known allergy to any components of the study product
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sydney Children's Hospital
Randwick, New South Wales, Australia, 2031
Actively Recruiting
Research Team
K
Keith CY Ooi
CONTACT
J
Jessica Halim
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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